78355-18-7Relevant academic research and scientific papers
Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT: Chemical Synthesis and in Vitro Evaluation of the Entire Positional Isomer Library of ortho-Carboranylmethyl-Bearing Glucoconjugates
Matovi?, Jelena,J?rvinen, Juulia,Sokka, Iris K.,Imlimthan, Surachet,Raitanen, Jan-Erik,Montaser, Ahmed,Maaheimo, Hannu,Huttunen, Kristiina M.,Per?niemi, Sirpa,Airaksinen, Anu J.,Sarparanta, Mirkka,Johansson, Mikael P.,Rautio, Jarkko,Ekholm, Filip S.
, p. 285 - 304 (2020/12/21)
Boron neutron capture therapy (BNCT) is a noninvasive binary therapeutic modality applicable to the treatment of cancers. While BNCT offers a tumor-targeting selectivity that is difficult to match by other means, the last obstacles preventing the full har
CARBOHYDRATE-MEDIATED TUMOR TARGETING
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, (2011/02/24)
Tumors can be selectively targeted via compounds provided herein according to the formula, or a pharmaceutically acceptable salt thereof, wherein RA and RB are as defined herein. Tumors can be imaged or targeted for therapeutic treat
Access to new carbohydrate-functionalized polylactides via organocatalyzed ring-opening polymerization
Miao, Yong,Rousseau, Cyril,Mortreux, André,Martin, Patrick,Zinck, Philippe
, p. 5018 - 5026 (2012/06/29)
The 4-dimethylaminopyridine (DMAP) catalyzed ring-opening polymerization of lactide using various carbohydrate initiators has been assessed for the functionalization of polylactide. Selectively protected glucose derivatives bearing a free primary alcohol (Glc-1r) and a free secondary alcohol (Glc-2r), glucose and cyclodextrin diol derivatives (Glc-diol and CD-diol), methyl-α-d-glucopyranoside (Glc-Me) and native β-cyclodextrin (CD) were used as initiators. According to the solubility of the carbohydrate derivative, the polymerizations were conducted in chlorinated solvents and in the bulk. Relatively narrow distributions are obtained in high yields in the absence of side reactions, affording a 100% functionalization efficiency. The catalytic synthesis of new carbohydrate link-functionalized polylactides and carbohydrate core star polylactides is reported.
Total synthesis of bleomycin A2 and related agents. 4. Synthesis of the disaccharide subunit: 2-O-( 3-O-Carbamoyl-α-D-mannopyranosyl)-L-gulopyranose and completion of the total synthesis of bleomycin A2
Boger, Dale L.,Honda, Takeshi
, p. 5647 - 5656 (2007/10/02)
The chemical synthesis of 2-O-(3-O-carbamoyl-α-D-mannopyranosyl)-L-gulopyranose and its incorporation into a total synthesis of bleomycin A2 (1) readily adaptable to the preparation of structural analogs are detailed. Key strategic elements of
The synthesis and characterization of 2-O-(6-O-L-glycero-α,β-D-manno-heptopyranosyl-α-D-glucopyranosyl)-α,β-D-glucopyranose
Nopogodev, Sergey A.,Pakulski, Zbigniew,Zamojski, Aleksander,Holst, Otto,Brade, Helmut
, p. 33 - 46 (2007/10/02)
The title compounds were synthesized, and appropriate derivatives were characterized by GLC, GLC-MS, and NMR spectroscopy.The GLC and GLC and GLC-MS data proved 2-O-(6-O-L-glycero-α-D-manno-heptopyranosyl-α-D-glucopyranosyl)-D-glucopyranose to be a consti
Synthesis of the Carbohydrate Moiety of Bleomycin. 1,3,4,6-Tetra-O-substituted L-Gulose Derivatives
Katano, Kiyoaki,Chang, Pei-In,Millar, Alan,Pozsgay, Vince,Minster, David K.,et al.
, p. 5807 - 5815 (2007/10/02)
To facilitate the synthesis of the carbohydrate moiety of bleomycin and its subsequent attachment to the remainder of the bleomycin molecule in a regio- and stereocelective fashion, a number of suita
