78355-92-7Relevant academic research and scientific papers
Synthesis and biological evaluation of certain new cyclohexane-1-carboxamides as apoptosis inducers
Abd-Allah, Walaa Hamada,Elshafie, Mohamed Fathy
, p. 825 - 833 (2018/05/28)
Series of 1-(N-phenyl-2-(heteroalicyclic-1-yl)acetamido)cyclohexane-1-carboxamide derivatives (5a-m) and 1-(phenyl(heteroalicyclic-1-ylmethyl)amino)cyclohexane-1-carboxamide (6a-f) were designed and synthesized with biological interest through coupling of 1-(2-chloro-N-phenylacetamido)cyclohexane-1-carboxamide (4) and (phenylamino)cycloakanecarboxamide (2) with different amines. The structures of the target compounds were elucidated via IR, 1H and 13C NMR, MS, and microanalysis. Compounds 5a-m and 6a-f were evaluated for their in vitro antitumor activity against four different cancer cell lines, MCF-7, HepG2, A549, and Caco-2. Compound 5i exhibited a promising activity against breast cancer cell line (IC50 value = 3.25 μM) compared with doxorubicin (IC50 value = 6.77 μM). Results from apoptosis and cell cycle analysis for compound 5i revealed good antitumor activity against MCF-7 cancer cell line and potent inhibition.
Search for Newer Analgesic Agents: Part I - Synthesis of 1-Arylaminocyclohexane-1-carboxamide Derivatives
Singh, G. B.,Jetley, Aruna,Rathore, H. G. S.
, p. 76 - 77 (2007/10/02)
N-(Substituted aminomethyl)-1-arylaminocyclohexane-1-carboxamides have been synthesized in which nitrogen of the amide group is linked through a methylene side chain with basic fragments like pyrrolidino, piperidino, morpholino, etc.These compounds contai
