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Relevant academic research and scientific papers

Muscle-relaxant 1,3,4-thiadiazin-2-amines

A method of achieving a muscle-relaxing effect in a patient comprises administering to a patient in which a muscle relaxing effect is desired an amount effective to achieve a muscle-relaxing effect of a compound of the formula STR1 wherein R is H, or C1-7 straight or branched chain alkyl; R1 is H, C1-7 straight or branched chain alkyl, allyl or phenyl; R2 is phenyl, phenyl monosubstituted with F, Cl, C1-4 straight or branched chain alkyl or phenyl disubstituted in the 2- and 4-positions with Cl or C1-4 straight or branched chain alkyl; and R3 is H or C1-4 straight or branched chain alkyl, with the proviso that when R3 is straight or branched chain alkyl, R2 is unsubstituted phenyl; or a pharmaceutically acceptable acid addition salt thereof.

5-(Chlorophenyl)-6H-1,3,4-thiadiazine-2-amines

Compounds of the formula STR1 wherein R is H, C1-5 or 7 -straight or branched chain alkyl or allyl and R1 is H or Cl and the pharmacologically acceptable acid addition salts thereof are pharmacologically active as anticonvulsant and anxiolytic agents.

5-(Optionally substituted phenyl)-6H-1,3,4-thiadiazine-2-amines

A method of inducing sedation in a patient comprises administering to a patient in which sedation is desired an amount effective for inducing sedation of a compound of the formula STR1 wherein R is H, or C1-5 or 7 -straight or branched chain alkyl: R1 is H, C1-5 or 7 -straight or branched chain alkyl or allyl; R2 is phenyl or phenyl substituted with F, Cl, Br, NO2, C1-5 straight or branched chain alkyl, C1-5 straight or branched chain alkoxy, 2,4-di-Cl, 2,4-di-F or 2,4-di-Br, with the proviso that when the phenyl group is monosubstituted with F, the F atom is not in the o-position; and R3 is H or C-1-5 straight or branched chain alkyl, with the proviso that when R3 is straight or branched chain alkyl, R2 is unsubstituted phenyl; or a pharmaceutically acceptable acid addition salt thereof.