78366-44-6Relevant academic research and scientific papers
Remote asymmetric induction in an intramolecular ionic Diels-Alder reaction: Application to the total synthesis of (+)-dihydrocompactin
Sammakia, Tarek,Johns, Deidre M.,Kim, Ganghyeok,Berliner, Martin A.
, p. 6504 - 6505 (2007/10/03)
The total synthesis of (+)-dihydrocompactin via an intramolecular ionic Diels-Alder reaction that proceeds with remote stereocontrol is described. This reaction proceeds by an intermediate vinyl-oxocarbenium ion (6), the conformational constraints of whic
Total Synthesis of (+)-Dihydrocompactin
Hagiwara, Hisahiro,Kon-no, Masakazu,Nakano, Takashi,Uda, Hisashi
, p. 2417 - 2430 (2007/10/02)
The total synthesis of (+)-dihydrocompactin 1 has been achieved by employing double Michael reaction of 3-(tert-butyldimethylsiloxy)-1-acetylcyclohexene 13 with methyl crotonate and the TiCl4-promoted aldol condensation of the bis(trimethylsilyl enol ethe
Synthesis of (+)-dihydrocompactin and (+)-compactin via vinylsilane terminated cationic cyclization
Burke, Steven D.,Deaton, David N.
, p. 4651 - 4654 (2007/10/02)
Two enantioselective routes to the octalin diol 1 are described, featuring cationic polyene cyclization mediated by a vinylsilane terminating group and a benzenedimethanol acetal initiator. Further transformations resulting in formal and total syntheses o
Total Synthesis of (+)-Dihydrocompactin
Yang, Yuh-Lin,Manna, Sukumar,Falck, J. R.
, p. 3811 - 3814 (2007/10/02)
The potent hypocholesterolemic agent (+)-dihydrocompactin was synthesized by union of the masked lactone 5, ultimately derived from a carbohydrate precursor with the requisite absolute configuration, and hydronaphthalene 10, which was obtained from maleic
