78371-66-1 Usage
Originator
Bucromarone,Transphyto
Uses
Different sources of media describe the Uses of 78371-66-1 differently. You can refer to the following data:
1. Cardiac depressant (anti-arrhythmic).
2. Bucromarone is an antiarrhythmic drug.
Manufacturing Process
1.2 mol of an electrophilic catalyst, advantageously aluminum chloride, was
slowly added to a solution of 48.8 g (0.4 mol) of 2,6-dimethyl phenol in 400
ml of dichloroethane and agitated at room temperature for an hour. The
mixture was cooled to 0°C and a solution of 84.0 g (0.4 mol) of 2-carboxylic
chromone acid chloride in 400 ml of a dichloroethane, was slowly added.
Agitation was continued at 0°C for 5 h and then at room temperature for 4
days. The reaction mixture was poured into 1.6 L of iced 50% hydrochloric
acid. The resulting precipitate was filtered, washed with water, dried and
106.0 g (72% yield) of 2-(3,5-dimethyl-4-hydroxybenzoyl)chromone, melting
point 216°C (recrystallised from dioxane) were obtained.
6.9 g (0.05 mol) of potassium carbonate was added to a solution of 29.4 g
(0.1 mol) of 2-(3,5-dimethyl-4-hydroxybenzoyl)chromone in 250 ml of
dimethyl formamide and kept at 100°C for an hour. A solution of 20.5 g (0.1
mol) of 3-N,N-dibutylamino-1-chloropropane in 100 ml of diethyl formamide
was then added and the resulting solution heated to 130°C for 3 h. The
solution was filtered, the dimethyl formamide was concentrated, dissolved in
300 ml water and extracted twice with 200 ml of benzene. The organic phase
was dried on magnesium sulfate and the hydrochloride was precipitated by
adding hydrochloric ether. 40.0 g (yield 80%) of 2-[4-(3-N,N-dibutylaminopropoxy)-
3,5-dimethylbenzoyl]chromone were obtained (recrystallised from an
acetone/ether mixture).
Check Digit Verification of cas no
The CAS Registry Mumber 78371-66-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,3,7 and 1 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 78371-66:
(7*7)+(6*8)+(5*3)+(4*7)+(3*1)+(2*6)+(1*6)=161
161 % 10 = 1
So 78371-66-1 is a valid CAS Registry Number.
InChI:InChI=1/C29H37NO4/c1-5-7-14-30(15-8-6-2)16-11-17-33-29-21(3)18-23(19-22(29)4)28(32)27-20-25(31)24-12-9-10-13-26(24)34-27/h9-10,12-13,18-20H,5-8,11,14-17H2,1-4H3
