78393-00-7

Upstream product

• 112-82-3 hexadecanyl bromide 
• 1137-42-4 4-Hydroxybenzophenone 

Downstream Products

• 78393-05-2 (4-Hexadecyloxy-phenyl)-diphenyl-methanol 
• 926292-00-4 4-cetyloxybenzophenone-(E)-3,5-dimethoxycarbonylphenylsulfohydrazone 
• 78421-07-5 1-{(2R,4S,5R)-5-[(4-Hexadecyloxy-phenyl)-diphenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-4-hydroxy-5-methyl-1H-pyrimidin-2-one 

Relevant academic research and scientific papers

Pharmacophore-based design of sphingosine 1-phosphate-3 receptor antagonists that include a 3,4-dialkoxybenzophenone scaffold

Sphingosine 1-phosphate (S1P) receptors are G-protein-coupled receptors. Among the five identified subtypes S1P1-5, the SIP3 receptor expressed on vascular endothelial cells has been shown to play an important role in cell proliferation, migration, and inflammation. A pharmacophore-based database search was used to identify a potent scaffold for an S1P3 receptor antagonist by common feature-based alignment and further validated using the Güner-Henry (GH) scoring method. Assumed excluded volumes were merged into this model to evaluate the steric effect with the S1P3 receptor. Three commercially available compounds were identified as S1P3 receptor antagonists, with IC50 values 3 receptor antagonist. Our results indicate that pharmacophore-based design of S1P3 receptor antagonists can be used to expand the possibility of structural modification through scaffold-hopping based on a database search.