78394-13-5Relevant academic research and scientific papers
Approach to trisubstituted 1 H -pyrroles from alkynoates and amines mediated by tert -butyl perbenzoate
Liu, Weibing,Tan, Liquan,Zhou, Peng,Chen, Cui,Zhang, Qing
supporting information, p. 991 - 994 (2013/06/27)
A simple and concise tandem cyclization of alkynoates with amines in the presence of tert-butyl perbenzoate (TBPB) leads to 1,2,4-trisubstituted 1H-pyrroles. A variety of aromatic amines and aliphatic amines can be used in this approach, and a wide range of functionalized 1,2,4-trisubstituted 1H-pyrroles are obtained in good to excellent yields. This protocol not only corresponds to the construction of a pyrrole fragment, but also provides a new way to form C-C and C-N bonds. Georg Thieme Verlag Stuttgart . New York.
Synthesis of polysubstituted pyrroles: Further advances in the reactivity of δ-dienamino esters
Agami, Claude,Dechoux, Luc,Hamon, Louis,Hebbe, Severine
, p. 859 - 862 (2007/10/03)
A series of polysubstituted pyrroles 3 have been synthesized efficiently in two or three steps starting from primary amines I. The key step of this process is the bromocyclization of δ-dienamino esters 2. The chemoselectivity of this reaction is discussed. AM1 calculations confirmed the observed reactivity.
Efficient and flexible access to polysubstituted pyrroles
Agami,Dechoux,Hebbe
, p. 1440 - 1442 (2007/10/03)
A series of polysubstituted pyrroles 3 have been synthesized very efficiently in two or three steps starting from primary amines 1. The key-step of this process is the bromocyclisation of δ-enaminoesters 2. The chemoselectivity of the reaction could depend on the nature of the solvent.
PHOTOLYSIS OF A 2-TETRAZENE FROM AN ENEHYDRAZINE
Luebbe, Fritz,Grosz, Klaus-Peter,Hillebrand, Wigbert,Sucrow, Wolfgang
, p. 227 - 228 (2007/10/02)
Photolysis of the 2-tetrazene 1 gives the triazole 2 by homolysis of one single N,N-bond.The formation of the other products 4 - 13 can be rationalized by regarding the aza-allyl radical 3 as a common precursor.
