784126-64-3Relevant academic research and scientific papers
Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: Part 2
Caldwell, John P.,Matasi, Julius J.,Fernandez, Xiomara,McLeod, Robbie L.,Zhang, Hongtao,Fawzi, Ahmad,Tulshian, Deen B.
scheme or table, p. 1164 - 1167 (2009/08/07)
A series of N-8 substituted analogs based upon the spiropiperidine core of the original lead compound 1 was synthesized. This lead has been elaborated to compounds to give compounds 2 and 3 (R = H) that exhibited high NOP binding affinity as well as selec
