78440-48-9Relevant academic research and scientific papers
Knoevenagel reaction in [MMIm][MSO4]: Synthesis of coumarins
Verdia, Pedro,Santamarta, Francisco,Tojo, Emilia
experimental part, p. 4379 - 4388 (2011/08/06)
The ionic liquid 1,3-dimethylimidazolium methyl sulfate, [MMIm][MSO 4], together with a small amount of water (the amount taken up by the ionic liquid upon exposure to air), acts efficiently as both solvent and catalyst of the Knoevenagel condensation reactions of malononitrile with 4-substituted benzaldehydes, without the need for any other solvent or promoter, affording yields of 92%-99% within 2-7 min at room temperature. When L-proline is used as an additional promoter to obtain coumarins from o- hydroxybenzaldehydes, the reaction also proceeds in high yields. Work-up is very simple and the ionic liquid can be reused several times. Some of the coumarins obtained are described for the first time.
Synthesis of 3-Coumaryl Phenyl Sulfones or Sulfoxides
Merchant, J.R.,,Shah, P.J.,
, p. 441 - 442 (2007/10/02)
An unambiguous synthesis of a number of 3-coumaryl phenyl sulfones or sulfoxides have been described which were obtained by the oxidation of the corresponding sulfides with hydrogen peroxide.The sulfides were prepared by the Perkin-Oglialore reaction of o-hydroxyaldehyde with the sodium salt of different S-phenyl thioacetic acids.The sulfones did not exhibit any appreciable antituberculous activity in the preliminary screening tests.
