78449-78-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(tetrahydro-1H-pyrrolizin-7a(5H)-yl)ethanamine (SALTDATA: FREE) is used as a pharmaceutical compound for its potential therapeutic applications. Its unique structure may contribute to the development of new drugs or drug candidates, targeting specific biological pathways or receptors.
Used in Chemical Processes:
In the chemical industry, 2-(tetrahydro-1H-pyrrolizin-7a(5H)-yl)ethanamine (SALTDATA: FREE) may serve as a key intermediate or reactant in the synthesis of other complex organic molecules. Its amine functionality and tetrahydropyrrolizine ring could be exploited in various chemical reactions, leading to the production of novel compounds with specific properties.

Upstream product

• 78449-75-9 (1-azabicyclo<3.3.0>octan-5-yl)acetonitrile 
• 20463-30-3 Δ¹⁽⁸⁾-dehydropyrrolizidine 
• 107825-25-2 (E)-4,4’,5,5’-tetrahydro-2’H,3H-[2,3’-bifuranylidene]-2’-one 
• 40624-07-5 1,7-dichloro-4-heptanone 

Downstream Products

• 236111-75-4 N-<2-(1-azabicyclo<3.3.0>octan-5-yl)ethyl>-4-(4-methoxybenzyloxy)-2-nitroaniline 
• 236111-70-9 5-(2-benzyloxycarbonylaminoethyl)-1-azabicyclo<3.3.0>octane 
• 905557-28-0 N-[4-[[2-(hexahydro-1H-pyrrolizin-7a-yl)ethylamino]methyl]-3-hydroxyphenyl]acetamide 
• 236111-76-5 N-<2-(1-azabicyclo<3.3.0>octan-2-one-5-yl)ethyl>-4-(4-methoxybenzyloxy)-2-nitroaniline 

Relevant academic research and scientific papers

Pyrrolizidines for direct air capture and CO2 conversion

Greenhouse gases such as CO2 strongly contribute to the rising temperatures of our planet, but as long as our society is dependent on fossil fuels, this trend will even increase in the near future. Therefore, CO2 capture and subseque

Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline

Two pyrrolizidinylalkyl derivatives of 4-amino-7-chloroquinoline (MG2 and MG3) were prepared and tested in vitro against CQ-sensitive and CQ-resistant strains of Plasmodium falciparum and in vivo in a Plasmodium berghei mouse model of infection. Both compounds exhibited excellent activity in all tests and low toxicity against mammalian cells. Preliminary studies of the acute toxicity and of the metabolism of the most active compound MG3 indicate a promising profile as a new antimalarial drug candidate.

Synthesis and muscarinic activity of a series of quinolines and naphthalenes with a 1-azabicyclo[3.3.0]octane moiety

In order to discover a medicine effective against Alzheimer's disease, we synthesized a series of quinoline derivatives having a characteristic 1- azabicyclo[3.3.0]octane amine ring, and performed pharmacological evaluation of them. Acetylcholine esterase inhibitory activities of these derivatives were unexpectedly weak. Tests for central nervous muscarinic cholinergic receptor binding affinity indicated that these compounds had higher affinities to muscarinic M1 receptors than to M2 receptors. A series of naphthalene derivatives substituted with the 1-azabicyclo[3.3.0]octane ring were also synthesized and muscarinic M1 and M2 receptor binding affinity determined. These compounds had much higher affinity for M1 receptors than the quinoline derivatives, and 1-[N-(1-azabicyclo[3.3.0]octan-5-yl)methyl-N- methylamino]-4-nitronaphthalene showed the highest affinity and selectivity. The ability of this compound to improve cognitive function was assessed using the passive avoidance test in scopolamine-induced mice.

N-[2-(1-azabicyclo[3.3.0]octan-5-YL)ethyl]-2-nitroaniline, a potent muscarinic agonist

The muscarine receptor agonist SK-946, an aniline derivative with a characteristic bicyclo amine, was found. We describe a new synthetic method for 1-azabicyclo[3.3.0]octane and describe the biological activity of SK- 946.

A NEW ROUTE TO 8-SUBSTITUTED PYRRAZOLIZIDINES

A new route to 8-substituted pyrrazolizidines starting with Δ4(8)-dehydropyrrolizidinium perchlorate is described.