78451-65-7Relevant academic research and scientific papers
A rapid and efficient microwave-assisted synthesis of hydantoins and thiohydantoins
Muccioli, Giulio G.,Poupaert, Jacques H.,Wouters, Johan,Norberg, Bernadette,Poppitz, Wolfgang,Scriba, Gerhard K.E.,Lambert, Didier M.
, p. 1301 - 1307 (2003)
The present paper describes studies on the synthesis of the antiepileptic drug phenytoin, and of structurally related derivatives. First, the influence of the solvent has been investigated in the microwave-assisted synthesis of the drug, resulting in a yield improvement and a cleaner reaction. Second, a two-step reaction is described to synthesize selectively and in high yields phenytoin. The first step consists in microwave activation of the reaction of benzil with thiourea, the second step includes the conversion of the resulting 2-thiohydantoin to phenytoin using hydrogen peroxide. Moreover, microwave activation is a very convenient method for the synthesis of 3-alkylated phenytoin derivatives, resulting in a much more selective method than the previously reported procedure using alkylating agents.
SYNTHESIS OF SOME 5,5-DISUBSTITUTED 2-THIOHYDANTOIN DERIVATIVES
Chiang, Hung-Cheh,Ko, Jin-Ren
, p. 529 - 530 (2007/10/02)
Treatment of 5,5-diphenyl-2-thiohydantoin (2a) with allyl bromide in basic alcohol solution gave 5,5-diphenyl-2-allylthiohydantoin (3a) in 78.5percent yield, whose derivatives (3b), (3f), (4a-c), and (6) were also prepared in a similar fashion.
SYNTHESES OF SOME 2-AMINO-5,5-DIPHENYLIMIDAZOLIN-4-ONE DERIVATIVES
Kiec-Kononowicz, Katarzyna,Zejc, Alfred
, p. 2217 - 2224 (2007/10/02)
Derivatives of 2-amino-5,5-diphenylimidazolin-4-one were obtained in a thermal reaction of 5,5-diphenyl-2-thiohydantoin with primary or secondary amines.Such compounds can be obtained also in the reaction of 2-ethylthiohydantoin with the above mentioned amines.Preliminary pharmacological testing of compound 7 for cardiovascular activity has been performed.
