78452-02-5

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 64152-76-7 methyl (S)-2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-4-methylpentanoate 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 61-90-5 L-leucine 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 33014-68-5 tert-butoxycarbonyl-L-phenylalanyl-L-leucine 
• 126369-84-4 N-tert-butyloxycarbonyl-L-phenylalanyl-L-leucine pentachlorophenyl ester 
• 7535-56-0 N-t-butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester 

Downstream Products

• 64410-79-3 L-tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucinol 
• 1334176-74-7 Z-Glu(OtBu)-Phe-Leu-H 
• 145997-32-6 Boc-Asp(OBzl)-Phe-Leu-H 
• 1334176-78-1 Boc-Glu(OBzl)-Phe-Leu-H 
• 1334176-80-5 Boc-Pro-Phe-Leu-H 
• 1334176-71-4 Cbz-L-Asp(OtBu)-L-Phe-L-leucinol 
• 1334176-72-5 Z-Asp(OtBu)-Phe-Leu-H 
• 1334176-69-0 C₂HF₃O₂*C₁₅H₂₄N₂O₂ 
• 169195-22-6 Boc-Phe-Leu-H 

Relevant academic research and scientific papers

An efficient method for the reduction of N-protected amino acids and peptides to the corresponding alcohols

Reduction of pentachlorophenyl esters of Boc protected amino acids and peptides to the corresponding alcohols is described.

An efficient entry to highly substituted chiral 2-oxopiperazines from α-amino acids via iodocyclization

A short and stereoselective route for the synthesis of 2-oxopiperazines is presented starting from different naturally abundant α-amino acids. The key synthetic steps involved amide coupling, Wittig reaction, HWE olefination, aza-Michael reaction, iodocyc

Synthesis and SAR study of novel peptide aldehydes as inhibitors of 20S proteasome

Based on the analysis of the crystal structure of MG101 (1) and 20S proteasomes, a new series of peptide aldehyde derivatives were designed and synthesized. Their ability to inhibit 20S proteasome was assayed. Among them, Cbz-Glu(OtBu)-Phe-Leucinal (3c), Cbz-Glu(OtBu)-Leu-Leucinal (3d), and Boc-Ser(OBzl)-Leu-Leucinal (3o) exhibited the most activity, which represented an order of magnitude enhancement compared with MG132 (2). The covalent docking protocol was used to explore the binding mode. The structure-activity relationship of the peptide aldehyde inhibitors is discussed.

A facile and simple method for the reduction of N-protected amino acids and peptides to the corresponding alcohols

A practical and chemoselective method for the reduction of N-protected amino acids and peptides including carboxylic acids to their corresponding alcohols is outlined.