78461-66-2

Upstream product

• 1489-97-0 ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate 
• 3618-04-0 4-hydroxycyclohexyl carboxylic acid ethyl ester 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 220934-71-4 1-hydroxymethyl-4,4-dimethoxy-cyclohexanecarboxylic acid ethyl ester 
• 78461-64-0 ethyl 1-hydroxymethyl-4-methylenedioxy-cyclohexane-1-carboxylate 
• 10029-04-6 ethyl 2-(hydroxymethyl)acrylate 
• 1449662-45-6 ethyl 1-(hydroxymethyl)-4-((trimethylsilyl)oxy)cyclohex-3-enecarboxylate 

Downstream Products

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 1449662-46-7 (1-(ethoxycarbonyl)-4-oxocyclohexyl)methyl benzoate 
• 220934-72-5 4-oxo-1-(toluene-4-sulfonyloxymethyl)-cyclohexanecarboxylic acid ethyl ester 

Relevant academic research and scientific papers

OXOLUPENE DERIVATIVES

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represen

TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY, SUBSTITUTED IN POSITION 3 BY A NON-AROMATIC RING CARRYING A HALOALKYL SUBSTITUENT

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: with X selected from C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6 cyclodialkenyl, C6 oxacyclodialkenyl, C6-9 oxaspirocycloalkyl and C6-9 oxaspirocycloalkenyl ring, such that X is substituted with A, wherein A is -C1-6 alkyl- halo. These compounds are useful for the treatment of HIV and AIDS.

C-3 CYCLOALKENYL TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-3 cycloalkenyl triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV: wherein X can be a C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6-9 oxaspirocycloalkyl, or C6-9 oxaspirocycloalkenyl ring. These compounds are useful for the treatment of HIV and AIDS.

The synthesis of [2.2.2]bicyclooctane and [3.1.1]bicycloheptane based amino acids as constrained glutamate analogues

A novel [2.2.2]bicyclooctane analogue of glutamic acid was synthesised using a modification of the Corey-Link amino acid synthesis. A related [3.1.1]bicycloheptane was prepared by cyclising a symmetrical 4,4- disubstituted cyclohexanone.