78462-57-4Relevant academic research and scientific papers
4-CHLOROPHENYL 5-CHLORO-8-QUINOLYL PHOSPHOROCHLORIDATE: A PRACTICALLY USEFUL PHOSPHORYLATING AGENT FOR OLIGORIBONUCLEOTIDE SYNTHESIS VIA PHOSPHOTRIESTER APPROACH
Takaku, Hiroshi,Yoshida, Masatoshi,Kamaike, Kazuo,Hata, Tsujiaki
, p. 197 - 200 (2007/10/02)
5'-O-Dimethoxytrityl-2'-O-tetrahydropyranylnucleosides (2) smoothly reacts with 4-chlorophenyl 5-chloro-8-quinolyl phosphorochloridate (1) prepared form 4-chlorophenyl phosphodichloridate and 5-chloro-8-hydroxyquinoline to give 5'-O-dimethoxytrityl-2'-O-tetrahydropyranylnucleoside 3'-(4-chlorophenyl, 5-chloro-8-quinolyl) phosphates (3) in high yields.They are key intermediates for the synthesis of oligoribonucleotides via phosphotriester approach.
4-CHLOROPHENYL 5-CHLORO-8-QUINOLYL PHOSPHOROTETRAZOLIDE: A HIGHLY EFFICIENT PHOSPHORYLATING AGENT FOR OLIGORIBONUCLEOTIDE SYNTHESIS
Takaku, Hiroshi,Nomoto, Tadaaki,Kamaike, Kazuo
, p. 543 - 546 (2007/10/02)
4-Chlorophenyl 5-chloro-8-quinolyl phosphorotetrazolide (2) was a highly efficient phosphorylating agent for the synthesis of 5'-O-dimethoxytrityl-2'-O-tetrahydropyranylnucleoside 3'-(4-chlorophenyl, 5-chloro-8-quinolyl) phosphates (4).The fully protected
