78477-91-5

Usage

Uses

Used in Flavor and Fragrance Industry:
8-Methyl-8-Azabicyclo[3.2.1]octan-2-one is used as a flavoring agent for its sweet floral and citrusy notes, enhancing the sensory experience of food products and fragrances.
Used in Pharmaceutical Synthesis:
8-Methyl-8-Azabicyclo[3.2.1]octan-2-one is utilized as a key intermediate in the synthesis of various pharmaceuticals, leveraging its unique structure and reactivity to produce a range of medicinal compounds.
Used in Organic Chemistry:
Pectinone is employed as a versatile building block in organic chemistry, contributing to the development of new organic compounds and materials due to its chemical properties and reactivity.
Used in Research and Development:
8-Methyl-8-Azabicyclo[3.2.1]octan-2-one is used in research and development settings to explore its potential applications and to understand its chemical behavior, further expanding its utility in various industries.

Upstream product

• 99020-85-6 (+/-)-Anhydroecgonine amide 
• 7126-50-3 ethyl 5-formyl-1H-pyrrole-2-carboxylate 
• 123686-89-5 (1RS)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carbonitrile 
• 13612-59-4 cyclohepta-2,4,6-triene-1-carbonitrile 
• 91645-70-4 5-(2-ethoxycarbonyl-ethyl)-pyrrole-2-carboxylic acid ethyl ester 
• 93647-41-7 2-ethoxycarbonyl-5-(2'-ethoxycarbonylethyl)-1-methylpyrrolidine 
• 91691-27-9 ethyl 5-(3-ethoxy-3-oxopropyl)pyrrolidine-2-carboxylate 
• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 
• 436159-80-7 ethyl (E)-5-(3-ethoxy-3-oxoprop-1-en-1-yl)-1H-pyrrole-2-carboxylate 
• 91340-84-0 3-ethoxycarbonyl-8-methyl-8-azabicyclo[3.2.1]octan-2-one 

Downstream Products

• 78386-51-3 N-phenoxycarbonylnortropan-2-on 
• 13466-55-2 tropan-2α-ol 
• 13466-55-2 tropan-2β-ol 
• 1362740-75-7 8-methyl-2-phenyl-8-aza-bicyclo[3.2.1]octan-2-ol 
• 1363594-88-0 (1RS,2RS,5SR)-8-methyl-2-phenyl-8-aza-bicyclo[3.2.1]oct-2-ylamine 
• 78386-47-7 tropan-2β-yl toluene-p-sulphonate 
• 1352447-63-2 2-methoxy-N-((1R,2R,5S)-8-methyl-2-phenyl-8-aza-bicyclo[3.2.1]oct-2-yl)-6-methylsulfanyl-4-trifluoromethyl-benzamide 
• 1352447-61-0 2-methoxy-N-((1S,2S,5R)-8-methyl-2-phenyl-8-aza-bicyclo[3.2.1]oct-2-yl)-6-methylsulfanyl-4-trifluoromethyl-benzamide 

Relevant academic research and scientific papers

Chiral fluoro ketones for catalytic asymmetric epoxidation of alkenes with oxone

Two structurally dissimilar, chiral fluoro ketones have been prepared and their potential as enantioselective catalysts for asymmetric epoxidation with Oxone has been evaluated. The tropinone-based ketone (-)-5 was easily prepared and showed excellent reactivity but only modest enantioselectivity. The biphenyl-based ketone (-)-6 was prepared in a somewhat lengthy synthesis (along with its monofluoro and geminal fluoro analogues). This ketone exhibited only modest reactivity; 30 mol % of (-)-6 was needed to bring about complete conversion in a reasonable time. The enantioselectivity of this catalyst was generally much higher, but again very substrate dependent.

A facile and efficient synthesis of (±)-tropan-2-one

The facile and efficient multigram synthesis of (±)-tropan-2-one 1 was achieved in six steps (65% overall yield) from N-methyl-3-oxopyridyl hydroiodide 3.

Solvolytic Rearrangements of Azabicyclic Compounds. Part 2. Kinetics

Rates of solvolysis in aqueous ethanol and aqueous dioxan of three 2-exo-chloroazabicycloalkanes have been studied and first-order rare constants are derived and compared with published values for analogous compounds.Anchimeric assistance by the bridge N-atom is evidently not important in the rate-controlling step in these rearrangements, though it may occur to a minor extent in the case of 2-exo-chloro-7-methyl-7-azanorbornane.Solvolytic results for tropan-2β-yl toluene-p-sulphonate in aqueous ethanol and aqueous acetone mixtures are also reported and compared with literature data for the carbobicyclic and oxabicyclic analogues.