78499-27-1 Usage
Originator
Bermoprofen,ZYF Pharm Chemical
Manufacturing Process
A mixture of dl-2-[4-(2'-carboxymethyl-4'-methylphenoxy)phenyl]propionic
acid (15.3 g) and polyphosphoric acid (92 g) was heated with stirring at 110-
120°C for 2 hours. To the reaction mixture was added water and the resulting
mixture was extracted with chloroform. The organic layer was washed with
water, dried over anhydrous sodium sulfate and concentrated. The residue was
chromatographed on silica gel (75 g) using chloroform as an eluent to give a
crude product, which was recrystallized from toluene to give the dl-2-(8-
methyl-10,11-dihydro-11-oxodibenz[b,f]oxepin-2-yl)propionic acid (9.4 g,
65.3%), m.p. 128-129°C.
Check Digit Verification of cas no
The CAS Registry Mumber 78499-27-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,4,9 and 9 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 78499-27:
(7*7)+(6*8)+(5*4)+(4*9)+(3*9)+(2*2)+(1*7)=191
191 % 10 = 1
So 78499-27-1 is a valid CAS Registry Number.
78499-27-1Relevant academic research and scientific papers
Nonsteroidal Antiinflammatory Agents. 1. 10,11-Dihydro-11-oxodibenzoxepinacetic Acids and Related Compounds
Nagai, Yasutaka,Irie, Akira,Nakamura, Hideo,Hino, Katsuhiko,Uno, Hitoshi,Nishimura, Haruki
, p. 1065 - 1070 (2007/10/02)
10,11-Dihydro-11-oxodibenzoxepinacetic acids and related compounds were synthesized as potential antiinflammatory agents.Among them, 2-(8-methyl-10,11-dihydro-11-oxodibenzoxepin-2-yl)propionic acid (16b) and its thiepin analogue (16c) showed excellent antipyretic activity together with potent antiinflammatory and analgesic properties in biological tests.Structure-activity relationships are discussed.
Dibenz[b,f]oxepin and dibenzo[b,f]thiepin derivatives, process for preparation thereof, method of using the same, and compositions thereof
-
, (2008/06/13)
Novel dibenz[b,f]oxepin and dibenzo[b,f]thiepin derivatives of the formula STR1 wherein X is an oxygen or sulfur atom, each of R1 and R2 is a hydrogen atom or a methyl group, and R3 is a hydrogen atom or a 2-(2-hydroxyetho
