785-44-4

Upstream product

• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 
• 108-98-5 thiophenol 
• 624-49-7 dimethylfumarate 

Downstream Products

• 110211-09-1 2-phenylthiobutane-1,4-diol 
• 84649-29-6 2-Chloro-2-phenylsulfanyl-succinic acid dimethyl ester 
• 84649-34-3 2-Benzenesulfinyl-succinic acid dimethyl ester 
• 624-49-7 dimethylfumarate 
• 84649-35-4 dimethyl 2-(phenylsulfinyl)maleate 
• 84649-36-5 dimethyl 2-(phenylsulfinyl)fumarate 
• 59790-39-5 dimethyl 2-(phenylthio)-maleate 
• 59790-38-4 dimethyl (Z)-2-(phenylthio)-2-butenedioate 

Relevant academic research and scientific papers

KF/Al2O3-mediated Michael addition of thiols to electron-deficient olefins

Potassium fluoride supported on alumina efficiently catalyzes Michael addition of aromatic and aliphatic thiols to a variety of conjugated alkenes such as α,β-unsaturated carbonyl compounds, carboxylic esters, amides, nitriles and chalcones. The Michael adducts are produced in good to excellent yields and relatively in short times. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency. Copyright Taylor & Francis, Inc.

ASYMMETRIC MICHAEL ADDITION OF THIOPHENOL TO MALEIC ACID ESTERS

(S)-(-)-Diisopropyl phenylthiosuccinate (81percent optical purity) is prepared in 95percent yield by the asymmetric Michael addition of thiophenol to diisopropyl maleate in the presence of a catalytic amount of cinchonine.The succinate thus prepared is transformed into (R)-(+)-3,4-epoxy-1-butanol without racemization.