785015-46-5Relevant articles and documents
Stereo- and regiocontrolled syntheses of exomethylenic cyclohexane β-amino acid derivatives
Kiss, Loránd,Forró, Eniko,Orsy, Gy?rgy,ábrahámi, Renáta,Fül?p, Ferenc
, p. 21094 - 21101 (2016/01/25)
Cyclohexane analogues of the antifungal icofungipen [(1R,2S)-2-amino-4-methylenecy clopentanecarboxylic acid] were selectively synthesized from unsaturated bicyclic β-lactams by transformation of the ring olefinic bond through three different regio- and s
Selective syntheses of novel highly functionalized β- aminocyclohexanecarboxylic acids
Kiss, Loránd,Forró, Enik,Fül?p, Ferenc
scheme or table, p. 4438 - 4443 (2012/08/08)
Highly functionalized β-aminocyclohexanecarboxylate regio- and stereoisomers were synthetized from racemic unsaturated bicyclic β-lactams via enzymatic resolution, selective transformation of the C-C double bond by stereoselective epoxidation, and regiose
Synthesis of orthogonally protected azepane β-amino ester enantiomers
Kazi, Brigitta,Kiss, Loránd,Forró, Eniko,Fül?p, Ferenc
scheme or table, p. 82 - 85 (2010/03/01)
A simple and convenient route is presented for the preparation of regio- and stereoisomers of novel azepane β-amino esters, starting from bicyclic β-lactam isomers. The synthetic procedure consists of dihydroxylation of the olefinic bond of the alicyclic amino esters, followed by NaIO4-mediated cleavage of the diol intermediate and reductive ring closure, which furnishes novel regioisomeric 5-aminoazepane-4-carboxylate and 3-aminoazepane-4-carboxylates. This method also allows the preparation of amino esters with an azepane skeleton in enantiomerically pure form.