78502-77-9Relevant academic research and scientific papers
POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1
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Paragraph 0293; 0294, (2019/11/11)
Described are positive allosteric modulators of muscarinic acetylcholine receptor M1 (mAChR M1), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating neurological disorders, psychiatric disorders, or a combination thereof.
N-Bromosuccinimide Bromination of Substituted Methylthiazoles
Krieg, Benno,Mittner, Juergen
, p. 623 - 632 (2007/10/02)
Bromination of methylthiazoles with one unsubstituted position by N-bromosuccinimide may take place either at the methyl group, at the heterocyclic nucleus, or at both positions according to the nature of the second substituent.The ethoxycarbonyl group in the compounds 1a-3a directs the bromine into the side chain.So it is possible to obtain the tribromomethyl compounds 1d and 2d without bromination of the thiazole nucleus.In the phenyl-substituted methylthiazoles 4a-6a bromination takes place in the methyl group and in the heterocyclic nucleus. - The bromomethylthiazoles 1b-3b yield the vinylthiazoles 1k-3k by Wittig reaction.
