78503-96-5

Upstream product

• 4753-94-0 thiophene-2-carbonyl isocyanate 
• 1670-14-0 benzamidine monohydrochloride 
• 5813-89-8 2-thiophenylcarboxamide 
• 17513-09-6 N′-cyanobenzamidine 

Relevant academic research and scientific papers

Scalable Synthetic Strategy for Unsymmetrical Trisubstituted s-Triazines

A scalable synthetic strategy to produce a large variety of unsymmetrical trisubstituted 1,3,5-triazines was developed. This protocol applied in situ formed acyl isocyanate from amide to react with amidine, introducing two substituents to the 1,3,5-triazinone ring with a low production cost and a simple workup procedure. The scalability of this method was demonstrated by translating a small-scale procedure to a multi-kilogram-scale synthesis. Chlorination and a further coupling reaction with various nucleophiles could provide unsymmetrical trisubstituted 1,3,5-triazines bearing diverse functional groups.

Method for synthesizing 1, 3, 5-triazine derivative

The invention relates to a method for synthesizing a 1, 3, 5-triazine derivative, which is used for synthesizing a 1, 3, 5-triazinone compound and a 2, 4, 6-trisubstituted-1, 3, 5-triazine compound containing three different substituent groups. Synthesis of the 1, 3, 5-triazinone compound comprises the following steps: taking amide, oxalyl chloride and amidine as reaction substrates, and heating for reaction; the synthesis method of the 2, 4, 6-trisubstituted-1, 3, 5-triazine compound containing three different substituent groups comprises the following synthesis steps: by taking amide, oxalyl chloride and amidine as reaction substrates, heating and reacting to obtain a 1, 3, 5-triazinone compound; reacting the 1, 3, 5-triazinone compound, phosphorus oxychloride and triethylamine in acetonitrile to generate a 2-chloro-4, 6-disubstituted 1, 3, 5-triazine compound; and coupling the 2-chloro-4, 6-disubstituted 1, 3, 5-triazine compound with various nucleophilic reagents, so that the 2, 4, 6-trisubstituted-1, 3, 5-triazine compound containing three different substituent groups is prepared. The method is wide in application range and relatively high in reaction yield, provides a new way for synthesis of the 1, 3, 5-triazine derivative, and has a relatively strong industrial application prospect.

The Synthesis of Alkyl- and Aryl-Substituted 1,3,5-Triazines

The reaction of chloromethyleneiminium salts with N-cyanoamidines provides a new and versatile route to alkyl- and aryl-substituted 1,3,5-triazines.Variation of substituents in the starting materials allows the synthesis of monoaryl-, diaryl-, alkyl-aryl- and certain mono- and di-alkyl-1,3,5-triazines bearing a variety of other substituents including hydrogen, chlorine and O-, S- and N-radicals.The generally good yields, ready availability of starting materials, and the scope and facility of the reaction make it the method of choice for the synthesis of 1,3,5-triazines with these substitution patterns.