78508-22-2

Upstream product

• 60956-26-5 4-bromo-2-nitrotoluene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 119-32-4 4-Methyl-3-nitroanilin 

Downstream Products

• 52415-29-9 6-bromo-1H-indole 
• 207792-73-2 4'-Ethoxy-2-(4''-bromo-2''-nitrophenyl)acetophenone 
• 61-54-1 tryptamine 
• 96624-18-9 6-bromotryptamine 
• 319493-07-7 3-(2-nitrovinyl)-6-bromo-1H-indole 
• 929606-22-4 (2E)-3-(4-bromo-2-nitrophenyl)-2-(4-bromophenyl)prop-2-enoic acid 
• 929606-25-7 (2E)-3-(2-amino-4-bromophenyl)-2-(4-bromophenyl)prop-2-enoic acid 
• 929606-23-5 (2E)-3-(4-bromo-2-nitrophenyl)-2-(4-chlorophenyl)prop-2-enoic acid 
• 929606-26-8 (2E)-3-(2-amino-4-bromophenyl)-2-(4-chlorophenyl)prop-2-enoic acid 
• 5551-12-2 4-bromo-2-nitrobenzaldehyde 

Relevant academic research and scientific papers

Concerning the preparation of 6-bromotryptamine

Most of the previous syntheses of the marine natural product 6-bromotryptamine have almost certainly led to partial debromination resulting in an impure product containing tryptamine. We show that loss of bromine occurs when lithium aluminum hydride is employed as a reducing agent in the final reaction step leading to 6-bromotryptamine. Reductive-debromination is also likely to intrude during some of the syntheses of 6-bromoindole, the typical precursor to 6-bromotryptamine. None of the seven described syntheses of 6-bromotryptamine that involve a reduction sequence from 6-bromoindole have reported elemental analyses as a measure of purity.

First total synthesis of eudistalbin A

Eudistalbin A was isolated from marine tunicate eudistoma album and possess cytotoxic activity (ED50 50 value of 2.1 μmol/L using the metabolic assay MTT. All structures of new compounds were confirmed by 1H NMR, 13C NMR, HRMS and optical rotation.

Radioprotectors

A compound of the formula (Ib): wherein X is NCH3, Y is N, Z is N, R3 is N(CH3)2, and (a) R1 is CH3, R2, R4 and R5 to R11 are hydrogen or (b) R5 is CH3 and R1, R2, R4 and R6 to R11 are hydrogen, and salts and tautomers thereof.

Chemical compounds

Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.

Structure and Synthesis of a New Bromoindole from a Marine Sponge

The isolation of methyl (E)-3-(6-bromoindol-3-yl)prop-2-enoate (5) from a sponge of the genus Iotrochota is described; its structure, (5), was confirmed by synthesis.