78508-36-8Relevant academic research and scientific papers
CHEMICAL ENTITIES
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Page/Page column 102, (2014/09/29)
Provided are chemical entities selected from compounds of formula (I), wherein R1, R2 and m have meanings given in the description, and pharmaceutically acceptable salts, solvates and stereoisomers thereof, which are inhibitors of ATR and are potentially useful in the treatment of cancer. Further provided are pharmaceutical compositions of the chemical entities, combination products containing the chemical entities, the use of the compositions as therapeutic agents, and methods of treatment using these compositions.
Sodium Borohydride Reduction of Adducts of Primary Amines with Aldehydes and p-Thiocresol. The Alkylation of Heterocyclic and Aromatic Amino-compounds
Kemal, Oeznur,Reese, Colin B.
, p. 1569 - 1573 (2007/10/02)
p-Nitroaniline, 2-aminopyridine (1a), 4-aminopyridine (2a), 2-amino-4-methylpyrimidine (8a), 2-aminothiazole (10a), and 2-aminobenzimidazole (12a) react with aqueous formaldehyde and p-thiocresol in ethanol or methanol solution to give N-(p-tolylthiomethyl) derivatives , usually in high yields.When the latter compounds are heated, under reflux, with an excess of sodium borohydride in ethanol or 1,2-dimethoxyethane solution, the corresponding methylamino-compounds are obtained.By a similar two-step prosedure in which aqueous formaldehyde is replaced, as appropriate, by anhydrous acetaldehyde, propionaldehyde, or benzaldehyde, p-nitroaniline is converted into N-ethyl-p-nitroaniline, p-chloroaniline is converted into p-chloro-N-(n-propyl)aniline, (1a) is converted into the corresponding ethylamino- and benzylamino-compounds (1c) and (1d), respectively, and (10a) and (12a) are converted into their 2-N-(n-propyl) derivatives (10c) and (12c), respectively.
