78509-10-1

Upstream product

• 79-36-7 dichloroacethyl chloride 
• 33858-94-5 6,7-dimethoxy-4-phenyl-1,3(2H)-benzothiazine 

Downstream Products

• 1233241-27-4 C₁₈H₁₅Cl₂NO₅S 
• 33858-94-5 6,7-dimethoxy-4-phenyl-1,3(2H)-benzothiazine 

Relevant academic research and scientific papers

Staudinger and retro-Staudinger reactions. The dichloro-β-lactam moiety as a useful handle for the synthesis of 4-aryl-2H-1,3-benzothiazine 1,1-dioxides

The dichloro-β-lactam ring, obtained via Staudinger reaction of 4-aryl-2H-1,3-benzothiazines, proved to be a useful protecting strategy for the synthesis of 4-aryl-2H-1,3-benzothiazine 1,1-dioxides. After oxidation of the 1,1-dichloroazeto[2,1-c][1,3]-benzothiazin-2-ones, the thiazine ring could be recovered selectively and in good yield by treatment with base. Thus, novel 4-aryl-2H-1,3-benzothiazine 1,1-dioxides were obtained efficiently.