78525-34-5

Usage

Uses

Used in Pharmaceutical Industry:
Tetrakis(4-aminophenyl)ethene is utilized as a pharmaceutical intermediate for medical experimental research. Its unique structure and functional groups enable it to serve as a building block for the development of new drugs and therapeutic agents.
As a pharmaceutical intermediate, Tetrakis(4-aminophenyl)ethene is used for:
1. Facilitating the synthesis of complex organic molecules and drug candidates, given its reactive amino groups that can undergo various chemical reactions.
2. Exploring its potential as a precursor for the development of novel therapeutic agents, particularly those targeting specific biological pathways or diseases.
3. Enhancing the understanding of the compound's pharmacological properties and its interactions with biological systems, which can contribute to the advancement of drug discovery and development processes.

Upstream product

• 119-61-9 benzophenone 
• 6425-27-0 α,α-dibromodiphenylmethane 
• 632-51-9 1,1,2,2-tetraphenylethylene 
• 101636-04-8 tetrakis-(4-nitro-phenyl)-oxirane 
• 47797-98-8 1,1,2,2-tetrakis(4-nitrophenyl)ethene 
• 611-98-3 4,4'-diaminobenzophenone 
• 5397-81-9 dibromo-bis-(4-nitro-phenyl)-methane 

Downstream Products

• 110176-63-1 1,1,2,2-tetrakis-(4-amino-phenyl)-ethane 
• 78525-35-6 tetrakis(4-acetylaminophenyl)ethene 

Relevant academic research and scientific papers

Electrospinning Superassembled Mesoporous AIEgen-Organosilica Frameworks Featuring Diversified Forms and Superstability for Wearable and Washable Solid-State Fluorescence Smart Sensors

Flexible optical sensors are widely studied and applied in many fields. However, developing highly stable and washable wearable sensors in optics is still facing significant challenges. Here, we demonstrate an AIEgen-organosilica framework (TPEPMO) hybrid

Anion-coordination-induced turn-on fluorescence of an oligourea- functionalized tetraphenylethene in a wide concentration range

A tetrakis(bisurea)-decorated tetraphenylethene (TPE) ligand (L 2) was designed, which, upon coordination with phosphate ions, displays fluorescence "turn-on" over a wide concentration range, from dilute to concentrated solutions and to the sol

Ultrasmall Organic Nanoparticles with Aggregation-Induced Emission and Enhanced Quantum Yield for Fluorescence Cell Imaging

The use of fluorescence probes for biomedical imaging has attracted significant attention over recent years owing to their high resolution at cellular level. The probes are available in many formats including small particle size based imaging agents which

Quadruple hydrogen bonded hyperbranched supramolecular polymers with aggregation-induced emission for artificial light-harvesting

In the present work, a tetraphenylethylene (TPE) derivative with four ureidopyrimidinones (TPE-tetraUPy) was synthesized through a two-step reaction, which could make up supramolecular hyperbranched polymers in CHCl3 through quadruple hydrogen

Single-molecule conductance in a unique cross-conjugated tetra(aminoaryl)ethene

A 1,1,2,2-tetrakis(4-aminophenyl)ethene with three paths of π-conjugation, linear-cis, linear-trans and a cross-conjugation, has been prepared. The molecule is able to bind to gold electrodes forming molecular junctions for single-molecule conductance measurements. Only two regimes of conduction are found experimentally. The modelling of the conductance allows to assign them to through-bond transmission in the linear case, while the cross-conjugated channel is further assisted by through-space transmission, partially alleviating the destructive quantum interference. This journal is

COVALENT ORGANIC FRAMEWORKS AND APPLICATIONS AS PHOTOCATALYSTS

Described herein are covalent organic frameworks. The covalent organic frameworks have unique structural and physical properties, which lends them to be versatile in a number of different applications and uses. In one aspect, the covalent organic frameworks are composed of a plurality of fused aromatic groups and electron-deficient chromophores. The covalent organic frameworks are useful as photocatalysts in a number of different applications.

Stimuli-responsive transmembrane anion transport by AIE-active fluorescent probes

Anticancer drug resistance implicates multifunctional mechanisms, and hypoxia is one of the key factors in therapeutic resistance. Hypoxia-specific therapy is considered an extremely effective strategy to fight against cancer. The development of small molecule-based synthetic anion transporters has also recently drawn attention for their potential therapeutic applications against several ion-transport-associated diseases, such as cancer and others. Herein, we describe the development of a hypoxia-responsive proanionophore to trigger controlled transport of anions across membranes under pathogenic conditions. Herein, we report the development of tetraphenylethene (TPE)-based anion transporters. The sulfonium-linkedp-nitrobenzyl containing TPE-based proanionophore could be converted into a lipophilic fluorescent Cl?ion carrier in a hypoxic or reductive environment. Stimuli such as nitroreductase (NTR) and glutathione (GSH) mediated regeneration of the TPE-based active Cl?ion transporter also showed aggregation-induced emission (AIE) properties. We hypothesize that such hypoxia and reductive stimuli activatable proanionophores have tremendous potential to fight against channelopathies, including cancer.

Dissipative aggregation-induced emission behaviour of an amino-functionalized tetraphenylethene using a pH oscillator

A dissipative aggregation-induced emission (DAIE) system is successfully fabricated by coupling a stimuli-responsive AIE luminogens (AIEgens) with a pH oscillator. The novel DAIE system exhibits reversible, autonomous and sustainable AIE behaviour. Moreover, the DAIE behaviour can be regulated with the system temperature. The novel strategy will boost the development of bioinspired intelligent systems for real-world applications. This journal is

3D Covalent Organic Frameworks Selectively Crystallized through Conformational Design

We present a strategy whereby selective formation of imine covalent organic frameworks (COFs) based on linking of triangles and squares into the fjh topology was achieved by the conformational design of the building units. 1,3,5-Trimethyl-2,4,6-tris(4-for

Emission enhancement of cationic tetraphenylethylene derivatives by encapsulation in a cucurbit[10]uril host in water

Binding of a series of cationic tetraphenylethylene (TPE) derivatives with a cucurbit[10]uril (CB[10]) host has been investigated. Compared to the free forms, all guests exhibit fluorescence enhancement upon encapsulation by CB[10]. Thus, by restricting i