78531-29-0

Usage

Uses

Used in Organic Synthesis:
2-Amino-1,3-dimethoxypropane is used as a reagent for its nucleophilic properties, facilitating various chemical reactions, especially in the formation of amide and ester bonds.
Used in Pharmaceutical Synthesis:
In the Pharmaceutical Industry, 2-Amino-1,3-dimethoxypropane is used as a precursor for the synthesis of a wide range of pharmaceuticals, contributing to the development of new medications.
Used in Agrochemical Production:
2-Amino-1,3-dimethoxypropane is utilized as a starting material in the production of agrochemicals, playing a role in the creation of compounds that protect crops and enhance agricultural productivity.
Used in Fine Chemicals Synthesis:
In the Fine Chemicals Industry, 2-Amino-1,3-dimethoxypropane is employed as a precursor for synthesizing specialty chemicals used in various applications, including fragrances, dyes, and other high-value products.
Safety Precautions:
When working with 2-Amino-1,3-dimethoxypropane, it is crucial to adhere to proper safety measures due to its flammability and potential to cause irritation. This includes using personal protective equipment and handling the compound in a well-ventilated area to minimize health risks.

InChI:InChI=1/C5H13NO2/c1-7-3-5(6)4-8-2/h5H,3-4,6H2,1-2H3

Upstream product

• 453548-89-5 1,3-dimethoxy-2-azidopropane 

Relevant academic research and scientific papers

Mechanism of Helix Induction on a Stereoregular Poly((4-carboxyphenyl)acetylene) with Chiral Amines and Memory of the Macromolecular Helicity Assisted by Interaction with Achiral Amines

Cis-transoidal poly((4-carboxyphenyl)acetylene) (poly-1) is an optically inactive polymer but forms an induced one-handed helical structure upon complexation with optically active amines such as (R)-(1-(1-naphthyl)ethyl) amine ((R)-2) in DMSO. The complexes show a characteristic induced circular dichroism (ICD) in the UV-visible region of the polymer backbone. Moreover, the macromolecular helicity of poly-1 induced by (R)-2 can be "memorized" even after complete replacement of (R)-2 by various achiral amines. We now report fully detailed studies on the mechanism of the helicity induction and memory of the helical chirality of poly-1 by means of UV-visible, CD, and infrared spectroscopies. We have found that a one-handed helix is cooperatively induced on poly-1 upon the ion pair formation of the carboxy groups of poly-1 with optically active amines and that the bulkiness of the chiral amines plays a crucial role for inducing an excess of a single-handed helix. On the other hand, the free ion formation was found to be essential for the macromolecular helicity memory of poly-1 after the replacement of the chiral amine by achiral amines, since the intramolecular electrostatic repulsion between the neighboring carboxylate ions of poly-1 significantly contributes to reduce the atropisomerization process of poly-1. On the basis of the mechanism of helicity induction and the memory of the helical chirality drawn from the present studies, we succeeded in creating an almost perfect memory of the induced macromolecular helicity of poly-1 with (R)-2 by using 2-aminoethanol as an achiral chaperoning molecule to assist in maintaining the memory of helical chirality.

DERIVATIVES OF 4- (IMIDAZOL-5-YL)-2-(4-SULFOANILINO) PYRIMIDINE WITH CDK INHIBITORY ACTIVITY

Compounds of the formula (I): wherein R1, R2, R3, R4, R5 and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.