78560-65-3

Upstream product

• 904744-99-6 acetic acid 4-(4-methyl-2-oxo-2H-chromen-7-yloxy)-but-2-ynyl ester 
• 904744-95-2 benzoic acid 4-(4-methyl-2-oxo-2H-chromen-7-yloxy)-but-2-ynyl ester 
• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 904744-96-3 7-(4-hydroxy-but-2-ynyloxy)-4-methyl-chromen-2-one 

Relevant academic research and scientific papers

Microwave-assisted Claisen rearrangement. Application to the synthesis of Angelicin derivatives

4-(Hydroxy, chloro, amino, acetoxy and methoxy)-methyl- 4,5-dimethylangelicins were efficiently and rapidly synthesized via Claisen rearrangement of 4-methyl-7-[4-(hydroxy, chloro, amino, acetoxy and methoxy)-but-2-ynyloxy]-coumarins respectively under mi

Furocoumarin for the photochemotherapy of psoriasis and related skin diseases

A class of alkyl-substituted angular flurocoumarins, sometimes termed alkylangelicins, useful in the photochemotherapy of psoriasis and in other skin diseases characterized by cellular hyperproliferation or lack of skin pigmentation is disclosed for topical application or systemic administration. Compared with conventional psoralens the described compounds exhibit a lower risk of skin cancer, absence of phototoxicity problems anderithema to the patient so treated. One preferred compound is 5-methylangelicin.