78564-22-4

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 1030-27-9 4-dimethylamino-chalcone 
• 89451-44-5 4-(4-Dimethylamino-phenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile; compound with piperidine 

Downstream Products

• 1127227-35-3 ethyl 3-amino-4-[4-(dimethylamino)phenyl]-6-phenylthieno[2,3-b]pyridine-2-carboxylate 
• 1127227-34-2 1-{3-amino-4-[4-(dimethylamino)phenyl]-6-phenylthieno[2,3-b]pyridin-2-yl}ethanone 
• 1127227-36-4 {3-amino-4-[4-(dimethylamino)phenyl]-6-phenylthieno[2,3-b]pyridin-2-yl}(4-chlorophenyl)methanone 
• 1127227-24-0 2-({3-cyano-4-[4-(dimethylamino)phenyl]-6-phenylpyridin-2-yl}thio)acetamide 
• 78564-32-6 4-(4-Dimethylamino-phenyl)-2-ethylsulfanyl-6-phenyl-nicotinonitrile 

Relevant academic research and scientific papers

Synthesis, characterization, and reactions of pyridine-3-carbonitrile derivatives

2-Thioxopyridine-3-carbonitrile derivatives 6a-c reacted with several halogen containing reagents 7a-d to afford the corresponding thieno[2,3-b]pyridine derivatives 9a-l, respectively. Thieno[2,3-b]pyridines 9c, g,k used for the preparation of their corresponding carbohydrazide derivatives 10a-c which in turn, used as good synthons for the synthesis of N-phenylmethylenethieno[2,3-b]pyridine-2-carbohydrazides 13a-c, pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidinones 15a-c, 16a-c and 17 and 1,3,4-oxadiazole-2-thiols 20a-c and 21a-c via their reactions with benzaldehyde or benzylidenemalononitrile, triethylorthoformate and carbon disulfide followed by hydrazine hydrate respectively. Considering the data of IR, 1H NMR, mass spectra, and elemental analyses elucidated the chemical structures of the newly synthesized heterocyclic compounds. Copyright Taylor & Francis Group, LLC.

SYNTHESIS OF 3-CYANO-4,6-DIARYL-3,4-DIHYDROPYRIDINE-2-THIONES

3-Cyano-4,6-diaryl-3,4-dihydropyridine-2-thiones have been synthesized for the first time by the condensation of arylideneacetophenones or 1-piperidino-1-phenyl-2-benzoylethane with cyanothioacetamide and the 1,1-dicyano-2-aryl-3-benzoylpropane with hydrogen sulfide in the presence of bases.It has been established by PMR spectroscopy that 3-cyano-3,4-dihydropyridine-2-thiones exist in solutions in the form of mixture of cis and trans isomers.

SYNTHESIS AND SOME REACTIONS OF 3-CYANOPYRIDINE-2-THIONES

New method for the synthesis of 3-cyanopyridine-2-thiones by the reaction of δ-keto nitroles with sulfur and by condensation of chalcones or benzylideneacetone with cyanothioacetamide are given.The compounds obtained were used in various reactions for the preparation of alkylated products, disulfides, and condensed heterocycles, viz., thienopyridines and pyridothienopyrimidines.