785763-79-3Relevant academic research and scientific papers
Naphthyridine derivatives
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, (2008/06/13)
A compound of the formula (I): wherein Ring A is substituted or unsubstituted pyridine ring, Y is substituted or unsubstituted alkyl, etc., R1is hydrogen, or substituted or unsubstituted alkyl, etc., R2is hydrogen or lower alkyl, R3is lower alkyl, Z is 1) —D1—Q [D1is direct bond or divalent C1-8hydrocarbon, etc., Q is hydroxy, carboxyl, etc.], or 2) —D2M—E—W [D2is direct bond or divalent C1-8hydrocarbon, etc., M is oxygen, sulfur, etc., E is direct bond or divalent C1-8hydrocarbon, etc., W is hydroxyl, carboxyl, etc.], or a prodrug thereof, or a pharmaceutically acceptable salt of the same, which exhibits acyl-CoA: cholesterol acyl transferase (ACAT) inhibitory activity, and is useful as an agent for treatment of hyperlipidemia and atherosclerosis.
