785836-19-3Relevant academic research and scientific papers
Synthesis and conformational investigation of tetrapeptide analogues of the fragment B23-B26 of insulin
Rodrigues, Lígia M.,Fonseca, José I.,Maia, Hernani L.S.
, p. 8929 - 8936 (2007/10/03)
Tetrapeptides containing one of a set of four different α,α-dialkyl glycines at the C-terminus were synthesized by conventional methods in solution and their conformational behavior investigated by 1H NMR spectroscopy in connection with molecular mechanics calculations. The results were consistent with conformations stabilized by a γ-turn in the case of compounds with alkyl groups larger than methyl, while the corresponding Aib derivative did not exhibit intramolecular hydrogen bonding. Graphical Abstract
