78584-08-4

Usage

Uses

Used in Organic Synthesis:
2-Benzothiazolamine,4,7-dimethyl-(9CI) is used as a building block in the synthesis of various organic compounds. Its unique structure allows for the creation of a wide range of chemical entities, making it a valuable component in the development of new materials and compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-Benzothiazolamine,4,7-dimethyl-(9CI) is utilized as a key intermediate in the synthesis of drugs and pharmaceuticals. Its presence in the molecular structure can contribute to the desired pharmacological properties, such as improved potency, selectivity, or bioavailability.
Used in Agrochemicals:
2-Benzothiazolamine,4,7-dimethyl-(9CI) also finds application in the agrochemical industry, where it serves as a precursor for the development of pesticides, herbicides, and other crop protection agents. Its incorporation into these compounds can enhance their effectiveness and selectivity, leading to better agricultural outcomes.
Used in Research and Development:
2-Benzothiazolamine,4,7-dimethyl-(9CI) holds potential in research and development, particularly in the field of organic synthesis and medicinal chemistry. It can be employed to explore new synthetic pathways, investigate novel chemical reactions, and develop innovative therapeutic agents.

InChI:InChI=1/C9H10N2S/c1-5-3-4-6(2)8-7(5)11-9(10)12-8/h3-4H,1-2H3,(H2,10,11)

Upstream product

• 16738-19-5 1-(2,5-dimethylphenyl)thiourea 
• 95-78-3 2,5-Dimethylaniline 
• 1147550-11-5 ammonium thiocyanate 

Downstream Products

• 139331-75-2 2-amino-3,6-dimethylbenzenethiol 
• 148342-92-1 C₃₀H₂₈N₂O₂S₂ 
• 148342-94-3 C₃₂H₃₂N₂O₂S₂ 
• 148342-95-4 C₃₀H₂₆Br₂N₂O₂S₂ 
• 148342-97-6 C₃₀H₂₆Cl₂N₂O₂S₂ 
• 148342-96-5 C₃₀H₂₆Cl₂N₂O₂S₂ 
• 139331-49-0 2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-5,8-dimethyl-4H-benzo[1,4]thiazin-3-one; hydrochloride 

Relevant academic research and scientific papers

POLY HETEROCYCLIC CONJUGATES AND THEIR PHARMACEUTICAL USES

Compounds of Formula (I) shown below and a pharmaceutical composition containing one of the compounds: Each of the variables is defined herein. Also disclosed is a method of treating a condition associated with uncontrolled cell growth with a compound of Formula (I).

Design, Synthesis, and Biological Evaluation of 4-Phenoxyquinoline Derivatives Containing Benzo[d]thiazole-2-yl Urea as c-Met Kinase Inhibitors

A series of novel 4-phenoxyquinoline derivatives containing the benzo[d]thiazole-2-yl urea moiety were synthesized and evaluated for their cytotoxicity against the HT-29, MKN-45, and H460 cell lines. The structures of the target compounds were confirmed by 1H NMR and MS spectra. Most of them showed moderate to excellent potency against the three tested cell lines. Especially, compound 23 was identified a promising agent (c-Met IC50 = 17.6 nM), showing the most potent anticancer activities with IC50 values of 0.18, 0.06, and 0.01 μM against the HT-29, MKN-45, and H460 cell lines, respectively. The docking results of 23 with the c-Met kinase model 3LQ8 showed a specific binding mode between the ligand and the target protein.

Synthesis and biological activities of new 1,4-benzothiazine derivatives

New 2H-1,4-benzothiazin-3(4H)-one derivatives possessing (4-phenyl-1-piperazinyl)alkyl moieties at the 2-position were synthesized and tested for calcium antagonistic and calmodulin antagonistic activities. Antihypertensive effects in spontaneously hypertensive rats were also evaluated. In general, these compounds were rather weak calcium channel blockers, although, in contrast, many of them had moderate to potent calmodulin antagonistic activity, and 2-[3-(4-(4-fluorophenyl)-1-piperazinyl]propyl]-2H-1,4-benzothiazin-3(4H )-one derivatives 45, 74 and 75 showed potent antihypertensive effects.