78592-82-2Relevant articles and documents
Synthesis of the first 'inside-outside' eight-membered ring via ringclosing metathesis: A total synthesis of (+/-)-asteriscanolide
Krafft, Marie E.,Cheung, Yiu-Yin,Juliano-Capucao, Carmelinda A.
, p. 1020 - 1026 (2000)
A total synthesis of (+/-)-asteriscanolide which features two transition metal-mediated carbocyclic ring forming reactions as key elements of our strategy (Scheme 1) is described. The highly functionalized cyclopentenone 4, the product of a cobalt-mediated Pauson-Khand [2+2+l]cycloaddition, is the key starting point for the synthesis. Excellent regiocontrol was obtained in the intermolecular Pauson-Khand reaction. Further synthetic manipulations of 4 led to diene 16 which underwent ring-closing metathesis using (PPh3)2Cl2Ru(CHPh)] to provide the desired 'inside-outside' tricycle 17. Conversion of 17 to 1 was achieved in a minimal number of steps. The synthesis of asteriscanolide has been achieved in 19 steps and 12% overall yield.
A high yielding procedure for preparation of mono-carboxylate surrogates of allenic dicarboxylates and diesters
Pettus, Thomas R. R.,Schlessinger, Richard H.
, p. 3019 - 3025 (2002)
A high yielding procedure for preparation of various allenyl mono-carboxylates is presented.
Total synthesis of (±)-momilactone A
Germain, Julie,Deslongchamps, Pierre
, p. 5269 - 5278 (2002)
The first total synthesis of (±)-momilactone A was accomplished using a highly diastereoselective transannular Diels-Alder reaction on a trans-trans-cis macrocyclic triene.
Gold(i)-catalysed synthesis of a furan analogue of thiamine pyrophosphate
Iqbal, Amjid,Sahraoui, El-Habib,Leeper, Finian J.
, p. 2580 - 2585 (2014)
An analogue of thiamine having a furan ring in place of the thiazolium ring has been synthesised by a short and efficient route, involving gold(I)-catalysed cyclisation of an alkynyl alcohol to form the furan ring. The furan analogue of thiamine diphospha
Enantioselective total synthesis of (-)-ptilomycalin A
Overman, Larry E.,Rabinowitz, Michael H.,Renhowe, Paul A.
, p. 2657 - 2658 (1995)
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CYCLOALKYL-CONTAINING CARBOXYLIC ACIDS AND USES THEREOF
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Page/Page column 77; 78, (2021/06/26)
The present application discloses a compound of formula (I) or a salt thereof: (I) and compositions comprising such compound or salt thereof. The use of such compound, salt thereof or composition comprising same for treating anemia or leukopenia, fibrosis, cancer, hypertension and/or a metabolic condition in a subject is also disclosed.
DEGRADABLE POLYMERS OF A CYCLIC SILYL ETHER AND USES THEREOF
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Paragraph 0962-0963, (2020/03/01)
The present disclosure provides cyclic silyl ethers of the formula: and salts thereof. The cyclic silyl ethers may be useful as monomers for preparing polymers. Also described herein are polymers prepared by polymerizing a cyclic silyl ether and optionall
Lewis Acid Catalyzed Electrophilic Aminomethyloxygenative Cyclization of Alkynols with N, O-Aminals
Chen, Anrong,Yu, Houjian,Yan, Jiaqi,Huang, Hanmin
supporting information, p. 755 - 759 (2020/01/28)
Lewis acid enables the electrophilic carbooxygenative cyclization of alkynols with N,O-aminals. The new process proceeds efficiently under very mild conditions via a pathway that is opposite to classical carbo-metalation. These reactions exhibit broad substrate generality and functional group compatibility, leading to a wide variety of 5-8-membered oxacycles bearing diverse functional groups. The cyclization products can be elaborated via simple functional group transformations to generate synthetically useful oxacycles.
