78604-09-8

Upstream product

• 127528-38-5 benzyl-2-acetamino-2-deoxy-4,6-O-isopropylidene-3-O-methoxycarbonylmethyl-α-D-glucopyranoside 
• 100-51-6 benzyl alcohol 
• 13343-62-9 benzyl 2-acetamido-2-deoxy-α-D-glucopyranoside 
• 66026-10-6 N-((4aR,6S,7R,8R,8aS)-6-(benzyloxy)-8-hydroxy-2,2-dimethylhexahydropyrano[3,2-d][1,3]dioxin-7-yl)acetamide 
• 79-08-3 bromoacetic acid 
• 7512-17-6 N-Acetyl-D-glucosamine 

Downstream Products

• 210631-21-3 2-Tetradecyl-hexadecanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-propylcarbamoyl]-methoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester 
• 210631-20-2 Octadecanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-propylcarbamoyl]-methoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester 
• 210631-19-9 (R)-4-{(S)-2-[2-((2S,3R,4R,5S,6R)-3-Acetylamino-2-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy)-acetylamino]-butyrylamino}-4-carbamoyl-butyric acid benzyl ester 
• 210631-18-8 (R)-4-{(S)-2-[2-((4aR,6S,7R,8R,8aS)-7-Acetylamino-6-benzyloxy-2,2-dimethyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy)-acetylamino]-butyrylamino}-4-carbamoyl-butyric acid benzyl ester 

Relevant academic research and scientific papers

Convergent synthesis of novel muramyl dipeptide analogues: Inhibition of porphyromonas gingivalis-induced pro-inflammatory effects by high doses of muramyl dipeptide

Porphyromonas gingivalis (P.g.)-induced TNF-α can be affected by muramyl dipeptide (MDP) in a biphasic concentration-dependent manner. We found that in P.g.-exposed macrophages, treatment with 10 μg/mL of MDP (MDP-low) up-regulated TNF-α by 29%, while 100

Synthesis and immunomodulating activity of lipophilic analogs of N-acetylnormuramoyl-L-2-aminobutanoyl-D-isoglutamine

N-Acetylnormuramoyl-L-2-aminobutanoyl-D-isoglutamine (7) and its lipophilic 6-O-octadecanoyl (8) and 6-O-(2-tetradecylhexadecanoyl) (9) derivatives were prepared and their immunoadjuvant activity and pyrogenicity were tested. Compounds 8 and 9 are less pyrogenic than muramoyl-dipeptide (MDP) and norMDP analog 7. Both lipophilic derivatives 8 and 9 are better adjuvants than MDP in cell mediated immunity.