78605-13-7Relevant academic research and scientific papers
Pyrrolopyrazines as kinase inhibitors
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Page 7, (2010/02/05)
The invention relates to pyrrolo [2,3b]-pyrazine derivatives having the general formula (I) : ???wherein :R2 and R3 are identical or different and represent H, C1-C6 alkyl, said alkyl being a straight or branched-chain alkyl, which can be substituted,R6 i
Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects
Mettey, Yvette,Gompel, Marie,Thomas, Virginie,Garnier, Matthieu,Leost, Maryse,Ceballos-Picot, Irène,Noble, Martin,Endicott, Jane,Vierfond, Jean-Michel,Meijer, Laurent
, p. 222 - 236 (2007/10/03)
Cyclin-dependent kinases (CDKs) regulate the cell cycle, apoptosis, neuronal functions, transcription, and exocytosis. The observation of CDK deregulations in various pathological situations suggests that CDK inhibitors may have a therapeutic value. In th
Cyclisation par amination intramoleculaire dans la serie de la pyrazine.
Vierfond, Jean-Michel,Mettey, Yvette,Mascrier-Demagny, Line,Miocque, Marcel
, p. 1219 - 1222 (2007/10/02)
An original one-pot synthesis of 4,7-diazaindoles is achieved by metalation of methylpyrazines or methylquinoxaline which are then condensed with an aromatic nitrile : an intermediate imine-enamine is formed which leads, by intramolecular cyclization, to diazaindoles.
