78605-18-2Relevant academic research and scientific papers
Synthesis of Fused-Pyrazines via Palladium-Catalyzed Double Benzyl Isocyanide Insertion and Cross-Dehydrogenative Coupling
Senadi, Gopal Chandru,Guo, Bing-Chun,Chang, Yu-Ching,Hu, Wan-Ping,Wang, Jeh-Jeng
, p. 491 - 501 (2018)
A palladium-catalyzed cascade reaction has been realized for the synthesis of 5H-pyrrolo[2,3-b]pyrazines and 5H-pyrazino[2,3-b]indoles from benzyl isocyanide by choosing o-pivaloyloximes or o-iodoanilines as a suitable substrate. The key steps involved are (i) oxidative addition of palladium through N–O or C–I cleavage; (ii) migratory double isocyanide insertion; and (iii) cross-dehydrogenative coupling. Notable features are good functional group tolerance as well as formation of three C–C and one C–N bonds. (Figure presented.).
Cyclisation par amination intramoleculaire dans la serie de la pyrazine.
Vierfond, Jean-Michel,Mettey, Yvette,Mascrier-Demagny, Line,Miocque, Marcel
, p. 1219 - 1222 (2007/10/02)
An original one-pot synthesis of 4,7-diazaindoles is achieved by metalation of methylpyrazines or methylquinoxaline which are then condensed with an aromatic nitrile : an intermediate imine-enamine is formed which leads, by intramolecular cyclization, to diazaindoles.
