78609-60-6Relevant academic research and scientific papers
Synthesis, molecular docking and anticancer studies of peptides and iso-peptides
Jabeen, Farukh,Panda, Siva S.,Kondratyuk, Tamara P.,Park, Eun-Jung,Pezzuto, John M.,Ihsan-Ul-Haq,Hall, C. Dennis,Katritzky, Alan R.
, p. 2980 - 2984 (2015/06/22)
Chiral peptides and iso-peptides were synthesized in excellent yield by using benzotriazole mediated solution phase synthesis. Benzotriazole acted both as activating and leaving group, eliminating frequent use of protection and subsequent deprotection. The procedure was based on the hypothesis that epimerization should be suppressed in solution due to a faster coupling rate than SPPS. All the synthesized peptides complied with Lipinski's Ro5 except for the rotatable bonds. Inhibition of cell proliferation of cancer cell lines is one of the most commonly used methods to study the effectiveness of any anticancer agents. Synthesized peptides and iso-peptides were tested against three cancer cell lines (MCF-7, MDA-MB 231) to determine their anti-proliferative potential. NFkB was also determined. Molecular docking studies were also carried out to complement the experimental results.
Ligations of O-acyl threonine units to give native peptides via 5-, 8-, 9- and 10-membered cyclic transition states
Panda, Siva S.,Liaqat, Sumaira,Tiwari, Anand D.,Marwani, Hadi M.,Faidallah, Hassan M.,Rauf, Abdul,Hall, C. Dennis,Katritzky, Alan R.
, p. 9 - 18 (2015/03/03)
N-Acyl threonine isopeptides undergo acyl transfer in chemical ligations via 5-, 8-, 9- and 10-membered cyclic transition states to yield natural peptides, representing the first examples of successful isopeptide ligations from N-acyl threonine units.
Pseudo-prolines as a molecular hinge: Reversible induction of cis amide bonds into peptide backbones
Dumy, Pascal,Keller, Michael,Ryan, Declan E.,Rohwedder, Barbara,W?hr, Torsten,Mutter, Manfred
, p. 918 - 925 (2007/10/03)
Serine, threonine-derived (4S)-oxazolidine-4-carboxylic acid, and cysteine-derived (4R)-thiazolidinecarboxylic acid, denoted pseudo-proline (Xaa[Ψ(R1,R2)pro]), serve as structure disrupting, solubilizing building blocks in peptide sy
Amino Acids and Peptides. III. Synthesis of Model Peptides Related to Cytochrome P-450
Kawasaki, Koichi,Maeda, Mitsuko,Tamura, Hiromi,Ohashi, Sumiko,Yoshimura, Tetsuhiko,Hatayama Etsuji et al.
, p. 1717 - 1723 (2007/10/02)
Various tetra- and pentapeptides with Cys and Ser (Thr, Tyr, His) at the N- and C-terminals, respectively, were synthetized as model peptides of the apoprotein of cytochrome P-450.The optical spectra of synthetic peptide-hemin complexes were measured and the results are discussed.Keywords - cytochrome P-450; synthetic Cys-containing peptide; peptide-hemin complex; optical spectrum of peptide-hemin complex
