78626-44-5Relevant academic research and scientific papers
Structural analogues of the natural products magnolol and honokiol as potent allosteric potentiators of GABAA receptors
Fuchs, Alexander,Baur, Roland,Schoeder, Clara,Sigel, Erwin,Müller, Christa E.
supporting information, p. 6908 - 6917 (2015/02/02)
Biphenylic compounds related to the natural products magnolol and 4′-O-methylhonokiol were synthesized, evaluated and optimized as positive allosteric modulators (PAMs) of GABAA receptors. The most efficacious compounds were the magnolol analog 5-ethyl-5′-hexylbiphenyl-2,2′-diol (45) and the honokiol analogs 4′-methoxy-5-propylbiphenyl-2-ol (61), 5-butyl-4′-methoxybiphenyl-2-ol (62) and 5-hexyl-4′-methoxybiphenyl-2-ol (64), which showed a most powerful potentiation of GABA-induced currents (up to 20-fold at a GABA concentration of 3 μM). They were found not to interfere with the allosteric sites occupied by known allosteric modulators, such as benzodiazepines and N-arachidonoylglycerol. These new PAMs will be useful as pharmacological tools and may have therapeutic potential for mono-therapy, or in combination, for example, with GABAA receptor agonists.
CONVENIENT METHOD OF OBTAINING 2-CYANO-4-ALKYLPHENOLS, 4-CYANOPHENOL AND 4-CYANOANILINE.
Adamska,Dabrowski,Dziabuszek
, p. 93 - 99 (2007/10/02)
A convenient method is described of obtaining 2-cyano-4-alkylphenols and 4-cyanophenol by substituting brombine atom for the cyano group in the respective bromoanisoles and demethylation of the cyanoalkylanisoles. It is suggested to prepare 4-cyanoaniline by reduction of 4-cyano-nitrobenzene with aqueous hydrazine solutions.
LATERALLY SUBSTITUTED 4-n-ALKYLPHENYL 4-n-ALKYLBICYCLO(2. 2. 2)OCTANE-1-CARBOXYLATES.
Gray,Kelly
, p. 109 - 119 (2007/10/02)
Different substituents (fluoro, chloro, bromo, and cyano) have been separately introduced into the 2-position of the phenolic moiety of the 4-n-alkylphenyl 4-n-alkylbicyclo(2. 2. 2)octane-1-carboxylates to produce new series of low melting esters with lar
