78630-35-0

Basic information

• Product Name: 5-(4-bromophenyl)-5-ethylimidazolidine-2,4-dione
• Synonyms: 5-(4-bromophenyl)-5-ethylimidazolidine-2,4-dione
• CAS NO: 78630-35-0
• Molecular Weight: 283.125
• Mol File: 78630-35-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(4-bromophenyl)-5-ethylimidazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-bromophenyl)-5-ethylimidazolidine-2,4-dione(78630-35-0)
• EPA Substance Registry System: 5-(4-bromophenyl)-5-ethylimidazolidine-2,4-dione(78630-35-0)

Safety Data

• Hazardous Substances Data: 78630-35-0(Hazardous Substances Data)

Upstream product

• 10342-83-3 4'-Bromopropiophenone 
• 506-87-6 ammonium carbonate 

Relevant articles and documents

Identification and Profiling of Hydantoins - A Novel Class of Potent Antimycobacterial DprE1 Inhibitors

Tuberculosis is the leading cause of death worldwide from infectious diseases. With the development of drug-resistant strains of Mycobacterium tuberculosis, there is an acute need for new medicines with novel modes of action. Herein, we report the discovery and profiling of a novel hydantoin-based family of antimycobacterial inhibitors of the decaprenylphospho-β-d-ribofuranose 2-oxidase (DprE1). In this study, we have prepared a library of more than a 100 compounds and evaluated them for their biological and physicochemical properties. The series is characterized by high enzymatic and whole-cell activity, low cytotoxicity, and a good overall physicochemical profile. In addition, we show that the series acts via reversible inhibition of the DprE1 enzyme. Overall, the novel compound family forms an attractive base for progression to further stages of optimization and may provide a promising drug candidate in the future.

Hydantoins having RNase modulatory activity

The present invention relates to hydantoin derivatives having RNase H, polymerase and/or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the hydantoin derivatives, compositions containing the deri