78636-72-3Relevant academic research and scientific papers
Highly selective rhodium-catalyzed conjugate addition reactions of 4-oxobutenamides
Zigterman, Jamie L.,Woo, Jacqueline C. S.,Walker, Shawn D.,Tedrow, Jason S.,Borths, Christopher J.,Bunel, Emilio E.,Faul, Margaret M.
, p. 8870 - 8876 (2008/03/12)
(Chemical Equation Presented) A variety of 4-oxobutenamides 1 were subjected to rhodium-catalyzed conjugate addition with arylboronic acids providing high regio- and enantioselectivity (97:3 to >99:1, >96% ee) and moderate to excellent yields (54-99%). Th
Base-catalyzed stereoselective isomerization of electron-deficient propargylic alcohols to E-enones
Sonye, John P.,Koide, Kazunori
, p. 6254 - 6257 (2007/10/03)
We have developed highly stereoselective methods to isomerize electron-deficient propargylic alcohols to E-enones under mild conditions (EWG = electron-withdrawing group). Among weak bases we screened, catalytic (10-20 mol %) 1,4-diazabicyclo[2.2.2]octane (DABCO) was found to be effective in most cases. When the substrate is conjugated with an amide, the addition of sodium acetate catalyzed the isomerization.
A Novel Aromatic Electrophilic Substitution: Acylation of Aromatics with Cyclic Isoimidium Salts to Yield N,N-Disubstituted β-Aroylcarboxamides
Balaban, Alexandru R.,Balaban, Theodor-Silviu,Boyd, Gerhard V.
, p. 577 - 578 (2007/10/02)
Cyclic isoimidium perchlorates derived from N,N-diethylphthalamic acid and the monomorpholides of succinic and maleic acid react with benzene, toluene or anisole in the presence of aluminium chloride to give the corresponding β-aroylcarboxamides in modera
