78646-63-6Relevant academic research and scientific papers
Silver catalyzed decarbonylative [3 + 2] cycloaddition of cyclobutenediones and formamides
Ali, Sajjad,Gao, Jinming,Liu, Zhigang,Wang, Pengcheng,Wang, Zhengshen,Yu, Ruirui,Zheng, Huaiji
, (2021/06/02)
As an important moiety in natural products, N,O-acetal has attracted wide attention in the past few years. An efficient method to construct N,O-acetal has been developed. Using silver catalyst, cyclobutenediones were smoothly converted to the corresponding γ-aminobutenolides in the presence of formamides, in which cyclobutenediones likely proceed with a key decarbonylative [3 + 2] cycloaddition process. In this way, a series of products with varied substituents were isolated in moderate yield and fully characterized.
Preparation of aryl-substituted butenolides using mucohalic acids
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Page/Page column 8, (2008/06/13)
Methods and materials for preparing 3-aryl-2-buten-4-olides and 2,3-bisaryl-2-buten-4-olides are disclosed. The methods include reacting a mucohalic acid with a reducing agent to give a 2,3-dihalo-2-buten-4-olide, which undergoes at least one Pd catalyzed cross-coupling reaction with an arylboronic acid.
Reinvestigation of mucohalic acids, versatile and useful building blocks for highly functionalized alpha,beta-unsaturated gamma-butyrolactones.
Zhang,Blazecka, Peter G,Belmont, Daniel,Davidson, James G
, p. 4559 - 4561 (2007/10/03)
[reaction: see text] Mucohalic acids (mucochloric acid (1, 3,4-dichloro-5-hydroxy-5H-furan-2-one) and mucobromic acid (2, 3,4-dibromo-5-hydroxy-5H-furan-2-one)) are inexpensive, commercially available starting materials with multiple functional groups. These compounds have been modified by way of reduction followed by Suzuki cross-coupling reactions involving arylboronic acids to afford highly functionalized alpha,beta-unsaturated gamma-butyrolactones in excellent yield. The synthetic utility of these building blocks was effectively demonstrated through preparation of the antiinflammatory drug Vioxx.
The Preparation of Synthetic Analogues of Strigol
Johnson, Alan W.,Gowda, Gopala,Hassanali, Ahmed,Knox, John,Monaco, Sam,et al.
, p. 1734 - 1743 (2007/10/02)
A range of analogues of the natural germination stimulant, strigol, for parasitic weeds of the genera Striga and Orobanche, has been prepared.Most of the products contain an α-formyl-γ-lactone (or α-formyl-γ-lactam) grouping attached through an enol-ether linkage to the 5-position of a but-2-enolide.Some have shown sufficiently high activities as to warrant large-scale field trials.
