78648-37-0Relevant academic research and scientific papers
SULFONANILIDE AND BENZYLSULFONYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF
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, (2022/04/16)
The invention provides novel sulfonanilide and benzylsulfonyl derivatives, and compositions and methods of preparation and use thereof, that are useful in treating various diseases and disorders related to TRPML activities such as lysosome storage diseases, muscular dystrophy, age-related common neurodegenerative diseases, oxidative stress or reactive oxygen species (ROS) related diseases, and ageing.
Synthesis, structure and N-N bonding character of 1,1-disubstituted indazolium hexafluorophosphate
Ning, Yingtang,Kawahata, Masatoshi,Yamaguchi, Kentaro,Otani, Yuko,Ohwada, Tomohiko
, p. 1881 - 1884 (2018/02/23)
1,1-Disubstituted indazolium hexafluorophosphates were synthesized via intramolecular electrophilic amination reactions under mild conditions. The crystal structures were determined and are consistent with the presence of a stable N-N bond, which can be cleaved by hydrogenation. Both experimental and computational studies suggest a covalent bonding character of the N-N bond, with diminished aromaticity of the newly formed pyrazolium ring due to the quaternary ammonium atom (N1), in contrast to the aromatic character of the parent indazole.
