78657-15-5Relevant academic research and scientific papers
Reduction of 1-(2-Hydroxy-3,5-di-t-butylphenyl)pyridinium Halides and Their Zwitterions. Formation of Di- and Tetra-hydropyridobenzoxazoles
Fukata, Gouki,Itoh, Takashi,Mataka, Shuntaro,Tashiro, Masashi
, p. 327 - 332 (2007/10/02)
Reduction of 1-(2-hydroxy-3,5-di-t-butylphenyl)pyridinium halides (1a-d) and/or their zwitterions (2a-d) with Raney Ni-Al alloy, Raney Ni (W2) and NaBH4 were investigated.When (1) was treated with Ni-Al alloy in a mixture of methanol and 30percent aqueous
Cyclodienones. 7. Preparation and Reduction of 1-(3,5-Di-tert-butyl-2-hydroxyphenyl)pyridinium Halides
Fukata, Gouki,Itoh, Takashi,Tashiro, Masashi
, p. 4454 - 4458 (2007/10/02)
The reactions of 4-bromo- (1a) and 4-chloro-2,4,6-tri-tert-butyl-2,5-cyclohexadien-1-one (1b) with compounds such as pyridine (4a), α- (4b), β- (4c), and γ-picoline (4d), and 3,5-lutidine (4e) were carried out under various conditions to produce the corresponding 1-(3,5-di-tert-butyl-2-hydroxyphenyl)pyridinium halides (7) or their intramolecular salts (8).The reduction of 7 and 8 with NaBH4 in methanol afforded in good yields the corresponding tetrahydropyridine derivatives (21), which were reduced to o-piperidinophenols (22) by hydrogenation with Raney Ni (W2) catalyst in high yields.The reaction pathway of the formation of 7 is also discussed.
