786630-97-5Relevant academic research and scientific papers
Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective α-sulfone hydroxamates
Kolodziej, Stephen A.,Hockerman, Susan L.,Boehm, Terri L.,Carroll, Jeffery N.,Decrescenzo, Gary A.,McDonald, Joseph J.,Mischke, Debbie A.,Munie, Grace E.,Fletcher, Theresa R.,Rico, Joseph G.,Stehle, Nathan W.,Swearingen, Craig,Becker, Daniel P.
scheme or table, p. 3557 - 3560 (2010/09/04)
A series of phenyl piperidine α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing of MMP-1
