786652-79-7Relevant academic research and scientific papers
Concise synthesis of 1H-pyrazin-2-ones and 2-aminopyrazines
Adam, Isabelle,Orain, David,Meier, Peter
, p. 2031 - 2033 (2007/10/03)
Convenient syntheses of 1H-pyrazin-2-ones and 2-aminopyrazines are described. By coupling Boc-protected amino acids with α-amino ketones or with amino alcohols and subsequent oxidation, 1H-pyrazin-2-ones were obtained. Transformation into the corresponding pyrazine triflates and substitution with primary or secondary amines led to 2-aminopyrazines. Since these syntheses take advantage of the use of readily available starting materials (e.g., amino acids, aminoalcohols and amines) a variety of the entitled structures can be obtained in few, high yielding steps.
