78666-77-0Relevant academic research and scientific papers
Preparation of Certain Pyridopyrimidinones and Related Compounds as Candidate Fluorescent Probes for Hypoxic Cells in Solid Tumours
Parrick, John,Rarl, Harshad K.
, p. 2411 - 2433 (2007/10/02)
Non-fluorescent 3-nitropyridopyrimidin-4-ones have been prepared as potential molecular probes for hypoxia in solid tumours.Reduction of the nitro group was expected to occur in the hypoxic cells to give the corresponding fluorescent amino compounds.These amino compounds, produced by chemical reduction, were indeed fluorescent and some showed the desired large Stokes shifts together with an emitted light wavelength suitable for use in flow cytometry but the fluorescence quantum yields could be obtained in this series of compounds.
