786707-55-9

Upstream product

• 371-14-2 4-fluorophenylhydrazine 
• 1186045-62-4 (7α'S)-7α'-methyl-5'-oxo-2',3',5',6',7',7α'-thexahydrospiro[1,3-dioxolane-2,1'-indene]-6'-carbaldehyde 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 

Downstream Products

• 754235-92-2 (4αS,5R)-1-(4-fluorophenyl)-4α-methyl-5-(prop-2-en-1yl)-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol 
• 1299446-55-1 (4αS,5R)-1-(4-fluorophenyl)-4α-methyl-5-(prop-2-en-1yl)-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol 
• 1299446-56-2 {(4αS,5R)-1-(4-fluorophenyl)-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-yl}acetaldehyde 
• 1299446-61-9 2-{(4αS,5R)-1-(4-fluorophenyl)-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-yl}-1-(3-methylpyridin-2-yl)ethanol 
• 1299446-62-0 2-{(4αS,5R)-1-(4-fluorophenyl)-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-yl}-1-(3-methylpyridin-2-yl)ethanol 
• 1299446-08-4 (4αS,5R)-1-(4-fluorophenyl)-5-[2-hydroxy-2-(3-methylpyridin-2-yl)ethyl]-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol 
• 1299446-64-2 2-{(4αS,5R)-1-(4-fluorophenyl)-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-yl}-1-(pyridin-2-yl)ethanol 
• 1299446-63-1 2-{(4αS,5R)-1-(4-fluorophenyl)-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-yl}-1-(pyridin-2-yl)ethanol 
• 1299446-10-8 (4αS,5R)-1-(4-fluorophenyl)-5-[2-hydroxy-2-(pyridin-2-yl)ethyl]-4α-methyl-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-ol 
• 1299446-68-6 2-{(4αS,5R)-1-(4-fluorophenyl)-4a-methyl-5-5-[(triethylsilyl)oxy]-1,4,4α,5,6,7-hexahydrocyclopenta[f]indazol-5-yl}-1-(pyridin-2-yl)ethanone 
• 614763-02-9 (4αS)-1-(4-fluorophenyl)-4α-methyl-4,4α,6,7-tetrahydrocyclopenta[f]indazol-5(1H)-one 

Relevant academic research and scientific papers

HEXAHYDROCYCLOPENTYL[F]INDAZOLE PYRIDYL ETHANOLS AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS

The present invention encompasses compounds of Formula (I): or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of use are also included.

Novel ketal ligands for the glucocorticoid receptor: In vitro and in vivo activity

A novel series of selective ligands for the human glucocorticoid receptor is described. Structure-activity studies focused on variation of B-ring size, ketal ring size, and ketal substitution. These analogs were found to be potent and selective ligands fo