78679-16-0

Usage

Class

Psychoactive drug

Chemical Family

Benzodiazepines

Use

Anxiolytic (treatment of anxiety disorders and related conditions)

Mechanism of Action

Regulates levels of certain neurotransmitters in the brain, resulting in a calming and sedative effect

Potential for Abuse

Lower compared to other benzodiazepines

Side Effects

Drowsiness, dizziness, impaired coordination

Precaution

Should be used with caution and under medical supervision

Upstream product

• 3967-01-9 4-methyl-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Nuclear Magnetic Resonance Spectra of Psychotherapeutic Agents. V*-Conformational Analysis of 1,3,4,5-Tetrahydro-2H-1,5-benzodiazepin-2-ones

The conformational analysis of biologically active lofendazam (7-chloro-5-phenyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one) is carried out by means of lanthanide shift reagent assisted 1H NMR spectroscopy: the lanthanide induced shift computer simulation suggests that in deuteriochloroform the heterocyclic ring of lofendazam assumes a cycloheptene-like chair conformation, where 1-N moves away from trigonal stereochemistry to a very flattened pyramidal structure.At room temperature the conformational equilibrium is markedly shifted (85percent) towards the conformer showing pseudoaxial H-1 and 5-Ph.The remarkable influence of steric requirements is controlling conformation, and the importance of 3- and/or 4-methyl groups in hindering the ring inversion at room temperature, have been verified by conformational analysis of suitable analogous 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-ones.