78701-59-4Relevant academic research and scientific papers
Synthesis of the 1,3,4-Oxadiazole Core through Thermolysis of Geminal Diazides
Erhardt, Hellmuth,Mohr, Fabian,Kirsch, Stefan F.
, p. 5629 - 5632 (2016)
The thermolysis of geminal diazides derived from acylacetate compounds is an efficient tool for the rapid construction of the 1,3,4-oxadiazole core. While a broad range of ethyl esters undergoes smooth transformation to the desired heterocycles that contain the ester moiety in moderate to high yields, the analogous tert-butyl esters give rise to the oxadiazoles with acyl groups, presumably through a pathway of decarboxylation followed by a new acyl transfer.
Uracil compounds as P2-purinoreceptor 7-transmembrane G-protein coupled receptor antagonists
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, (2008/06/13)
Compounds of formula I or salts thereof where for example Y is a group of the formula (i) and R1is a group of formula (ii) are provided along with compositions containing them and processes for their preparation. The compounds are P2-purinoreceptor 7-transmembrane G-protein coupled receptor antagonists, and are useful in the treatment of inflammatory conditions.
