78711-30-5

Usage

Chemical compound

2-amino-6-methylpyrido[3,2-d]pyrimidin-4(1H)-one

Family

Pyrido[3,2-d]pyrimidin-4(1H)-one

Role

Important component of nucleic acids like DNA and RNA

Classification

Purine base

Function

Critical role in the structure and function of genetic material

Involvement

Formation of adenosine triphosphate (ATP)

Precursor for

Adenosine and adenosine monophosphate (AMP)

Significance

Widely studied in biochemistry, pharmacology, and molecular biology

Upstream product

• 30212-52-3 2,4-dichloropyrido<3,2-d>pyrimidine 
• 78711-28-1 2-chloro-6-methylpyrido<3,2-d>pyrimidin-4(3H)-one 
• 82933-87-7 2,4-diamino-6-methyl-pyrido<3,2-d>pyrimidine 

Downstream Products

• 76807-52-8 2-amino-6-hydroxymethyl-4-(3H)-pyrido<3,2-d>pyrimidinone 
• 78711-39-4 (S)-2-{4-[(2-Acetylamino-4-oxo-3,4-dihydro-pyrido[3,2-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid 
• 78711-35-0 N-<4-<<(2-amino-4(3H)-oxopyrido<3,2-d>pyrimidin-6-yl)carbonyl>amino>benzoyl>-L-glutamic acid 
• 51989-25-4 8-Deazafolic Acid 
• 246160-33-8 C₅₈H₆₆N₉O₁₆P 
• 246160-32-7 C₄₆H₅₅N₉O₁₄ 
• 246160-31-6 2-(4-{acryloyl-[2-(2,2-dimethyl-propionylamino)-4-oxo-3,4-dihydro-pyrido[3,2-d]pyrimidin-6-ylmethyl]-amino}-benzoylamino)-pentanedioic acid diethyl ester 
• 246160-30-5 2-(4-{[2-(2,2-dimethyl-propionylamino)-4-oxo-3,4-dihydro-pyrido[3,2-d]pyrimidin-6-ylmethyl]-amino}-benzoylamino)-pentanedioic acid diethyl ester 
• 78711-34-9 2-amino-5,6,7,8-tetrahydro-6-methylpyrido<3,2-d>pyrimidin-4(3H)-one trifluoroacetate 
• 78711-31-6 2-amino-4(3H)-oxopyrido<3,2-d>pyrimidine-6-carboxylic acid 

Relevant academic research and scientific papers

Pyridopyrimidines. 14. Conformational Studies of 5,6,7,8-Tetrahydropyridopyrimidines. Potential Multisubstrate Analogue Inhibitors of Thymidylate Synthetase

The synthesis of 5-pyrimidin-5-yl)methyl>-2'deoxyuridine and a number of related compounds as models of potent inhibitors of thymidylate synthetase has been accomplished.The 1H and 13C NMR spectra of certain of these molecules show unusual and remarkably stable conformational effects.A partial conformational analysis was undertaken in order to determine the origins of these effects.These studies revealed that the presence of a diastereomeric center at C-6 is responsible for the observed phenomena.

SYNTHESIS OF AN 8-DEAZA ANALOG OF THE INTERMEDIATE IN THE THYMIDYLATE SYNTHETASE REACTION

Synthesis of an 8-deaza analog of the proposed intermediate in the thymidylate synthetase rection was accomplished from diethyl 8-deazafolic acid and an unambiguous proof of the structure is provided.