78744-33-9Relevant academic research and scientific papers
PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
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Paragraph 00164, (2016/01/01)
The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof wherein n, m, R1, R2, R3, R4, and R5 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (ΡI3Κ) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more ΡI3Κ isoforms.
2,4-Diamo-5-(alkylsulfinyl) or alkylsulphonyl)-6-halopyrimidines
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, (2008/06/13)
The invention relates to novel 2,4-diamino-5-alkylsulfinyl- or -alkylsulfonyl-6-halopyrimidines of the formula STR1 wherein n is 1 or 2, R1 is C1 -C4 alkyl, each of R2 and R3 is hydrogen, C1 -C6 alkyl or C3 -C6 cycloalkyl and X is chlorine, bromine or fluorine. These compounds have selective herbicidal action and inhibit plant growth. They are obtained by amination of halogen-substituted or hydroxyl-substituted amino-5-alkylsulfinyl- and -sulfonylpyrimidines. The invention also relates to the production of 5-sulfinylpyrimidine intermediates.
