78752-75-7

Upstream product

• 78752-73-5 4,4-bis-(p-fluorophenyl)-3,3-dimethyl-1,2-oxathietan 2-oxide 
• 78752-71-3 2-hydroxy-2,2-bis-(p-fluorophenyl)-1,1-dimethylethyl t-butylsulphoxide 
• 345-92-6 4,4'-Difluorobenzophenone 
• 347192-81-8 P,P-diphenyl-P-(1-methylethyl)(N-methoxycabonyl)phosphazene 

Relevant academic research and scientific papers

Spiro[1,2]oxaphosphetanes of nonstabilized and semistabilized phosphorus ylide derivatives: Synthesis and kinetic and computational study of their thermolysis

A series of tri- and tetrasubstituted spiro-oxaphosphetanes stabilized by ortho-benzamide (oBA) and N-methyl ortho-benzamide (MoBA) ligands have been synthesized by the reaction of Cα,Cortho-dilithiated phosphazenes with aldehydes and ketones. They include enantiopure products and the first example of an isolated oxaphosphetane having a phenyl substituent at C3 of the ring. Kinetic studies of their thermal decomposition showed that the process takes place irreversibly through a polar transition state (ρ = -0.22) under the influence of electronic, [1,2], [1,3] steric, and solvent effects, with C3/P-[1,2] interactions as the largest contribution to ΔG of olefination. Inversion of the phosphorus configuration through stereomutation has been observed in a number of cases. DFT calculations showed that oBA derivatives olefinated through the isolated (N, O)(Ph, C6H4, C) oxaphosphetanes (Channel A), whereas MoBA compounds decomposed faster via the isomer (C6H4, O)(C, N, Ph) formed by P-stereomutation involving a MB2 permutational mechanism (Channel B). The energy barrier of P-isomerization is lower than that of olefination. Fragmentation takes place in a concerted asynchronous reaction. The thermal stability of oxaphosphetanes is determined by strong C3/P-[1,2] interactions destabilizing the transition state of olefination. The effect of charge distribution and C3/C4-[1,2] and C4/P-[1,3] steric and solvent interactions on ΔG was also evaluated.

Preparation of Stable β-Sultines. Crystal Structure of 2,2-Bis-(p-fluorophenyl)-3,3-dimethyl-1,2-oxathietan 2-Oxide

Three 4,4-diaryl-3,3-dimethyl-1,2-oxathietan 2-oxides were prepared by the oxidative cyclisation of 2-hydroxyalkyl t-butyl sulphoxides.They decomposed readily to 1,1-diaryl-2-methylprop-1-enes, but two of them were isolated in crystalline form.The determi